FBXW11 anticorps

N° du produit ABIN7114038

Cet anticorps anti-FBXW11 est un anticorps Lapin Polyclonal détectant FBXW11 dans WB et ELISA. Adapté pour Humain, Souris et Rat.

Aperçu rapide pour FBXW11 anticorps (ABIN7114038)

Antigène: FBXW11 (F-Box and WD Repeat Domain Containing 11 (FBXW11))

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp FBXW11 est non-conjugé

Application: Western Blotting (WB), ELISA

Détail du produit anti-FBXW11 anticorps

Fonction: FBXW11 antibody

Purification: Immunogen affinity purified

Pureté: ≥95 % as determined by SDS-PAGE

Immunogène: F-box and WD repeat domain containing 11

Isotype: IgG

Information d'application

Indications d'application: WB: 1:500-1:2000

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freeze / thaw cycles.

Stock: -20 °C

Stockage commentaire: -20°C for 12 months

Date de péremption: 12 months

Détails sur FBXW11

Antigène: FBXW11 (F-Box and WD Repeat Domain Containing 11 (FBXW11))

Autre désignation: FBXW11

Sujet:

Synonyms: F-box/WD repeat-containing protein 11|F-box and WD repeats protein beta-TrCP2|F-box/WD repeat-containing protein 1B|Homologous to Slimb protein (HOS)|FBXW11|BTRCP2|FBW1B|FBXW1B|KIAA0696

Background: Substrate recognition component of a SCF(SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Probably recognizes and binds to phosphorylated target proteins. SCF(FBXW11) mediates the ubiquitination of phosphorylated CTNNB1 and participates in Wnt signaling. SCF(FBXW11) mediates the ubiquitination of phosphorylated NFKBIA, which degradation frees the associated NFKB1 to translocate into the nucleus and to activate transcription. SCF(FBXW11) mediates the ubiquitination of IFNAR1. SCF(FBXW11) mediates the ubiquitination of CEP68, this is required for centriole separation during mitosis(PubMed:25503564). Involved in the oxidative stress-induced a ubiquitin-mediated decrease in RCAN1. Mediates the degradation of CDC25A induced by ionizing radiation in cells progressing through S phase and thus may function in the intra-S-phase checkpoint. Has an essential role in the control of the clock-dependent transcription via degradation of phosphorylated PER1 and phosphorylated PER2. Is target of human immunodeficiency virus type 1(HIV-1) protein VPU to polyubiquitinate and deplete BST2 from cells and antagonize its antiviral action.

Poids moléculaire: 61 kDa

ID gène: 23291

UniProt: Q9UKB1