FBXW5 anticorps

N° du produit ABIN7114041

Cet anticorps anti-FBXW5 est un anticorps Lapin Polyclonal détectant FBXW5 dans WB, ELISA et IHC. Adapté pour Humain, Souris et Rat.

Aperçu rapide pour FBXW5 anticorps (ABIN7114041)

Antigène: FBXW5 (F-Box and WD Repeat Domain Containing 5 (FBXW5))

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp FBXW5 est non-conjugé

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC)

Détail du produit anti-FBXW5 anticorps

Fonction: FBXW5 antibody

Purification: Immunogen affinity purified

Pureté: ≥95 % as determined by SDS-PAGE

Immunogène: F-box and WD repeat domain containing 5

Isotype: IgG

Information d'application

Indications d'application: WB: 1:500-1:2000, IHC: 1:20-1:200

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freeze / thaw cycles.

Stock: -20 °C

Stockage commentaire: -20°C for 12 months

Date de péremption: 12 months

Détails sur FBXW5

Antigène: FBXW5 (F-Box and WD Repeat Domain Containing 5 (FBXW5))

Autre désignation: FBXW5

Sujet:

Synonyms: F-box/WD repeat-containing protein 5|F-box and WD-40 domain-containing protein 5|FBXW5|FBW5

Background: Substrate recognition component of both SCF(SKP1-CUL1-F-box protein) and DCX(DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complexes. Substrate recognition component of the SCF(FBXW5) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of SASS6 during S phase, leading to prevent centriole reduplication. The SCF(FBXW5) complex also mediates ubiquitination and degradation of actin-regulator EPS8 during G2 phase, leading to the transient degradation of EPS8 and subsequent cell shape changes required to allow mitotic progression. Substrate-specific adapter of the DCX(FBXW5) E3 ubiquitin-protein ligase complex which mediates the polyubiquitination and subsequent degradation of TSC2. May also act as a negative regulator of MAP3K7/TAK1 signaling in the interleukin-1B(IL1B) signaling pathway.

Poids moléculaire: 65 kDa

ID gène: 54461

UniProt: Q969U6