HNRNPC anticorps

N° du produit ABIN7114978

Cet anticorps Lapin Polyclonal détecte spécifiquement HNRNPC dans WB, IHC, ELISA, IF et FACS. Il présente une réactivité envers Humain, Rat et Souris.

Aperçu rapide pour HNRNPC anticorps (ABIN7114978)

Antigène: HNRNPC (Heterogeneous Nuclear Ribonucleoprotein C (C1/C2) (HNRNPC))

Reactivité: Humain, Rat, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp HNRNPC est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC), ELISA, Immunofluorescence (IF), Flow Cytometry (FACS)

Détail du produit anti-HNRNPC anticorps

Fonction: HNRNPC antibody

Purification: Immunogen affinity purified

Pureté: ≥95 % as determined by SDS-PAGE

Immunogène: heterogeneous nuclear ribonucleoprotein C(C1/C2)

Isotype: IgG

Information d'application

Indications d'application: WB: 1:500-1:2000, IHC: 1:20-1:200, IF: 1:20-1:200

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freeze / thaw cycles.

Stock: -20 °C

Stockage commentaire: -20°C for 12 months

Date de péremption: 12 months

Détails sur HNRNPC

Antigène: HNRNPC (Heterogeneous Nuclear Ribonucleoprotein C (C1/C2) (HNRNPC))

Autre désignation: HNRNPC

Sujet:

Synonyms: Heterogeneous nuclear ribonucleoproteins C1/C2 (hnRNP C1/C2)|HNRNPC|HNRPC

Background: Binds pre-mRNA and nucleates the assembly of 40S hnRNP particles(PubMed:8264621). Specifically recognizes and binds N6-methyladenosine(m6A)-containing RNAs, a modification present at internal sites of mRNAs that affects mRNA splicing, processing and stability. M6A alters the local structure in mRNAs and long non-coding RNAs(lncRNAs) via a mechanism named 'm(6)A-switch' to facilitate binding of HNRNPC, leading to regulation of mRNA splicing(PubMed:25719671). Single HNRNPC tetramers bind 230-240 nucleotides. Trimers of HNRNPC tetramers bind 700 nucleotides. May play a role in the early steps of spliceosome assembly and pre-mRNA splicing. Interacts with poly-U tracts in the 3'-UTR or 5'-UTR of mRNA and modulates the stability and the level of translation of bound mRNA molecules(PubMed:12509468, PubMed:16010978, PubMed:7567451, PubMed:8264621).

Poids moléculaire: 32 kDa

ID gène: 3183

UniProt: P07910