IFITM3 anticorps (AA 1-133)

N° du produit ABIN7115388

Cet anticorps anti-IFITM3 est un anticorps Souris Monoclonal détectant IFITM3 dans WB, ELISA, IHC, IF et FACS. Adapté pour Humain.

Aperçu rapide pour IFITM3 anticorps (AA 1-133) (ABIN7115388)

Antigène: IFITM3 (Interferon-Induced Transmembrane Protein 3 (IFITM3))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp IFITM3 est non-conjugé

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF), Flow Cytometry (FACS)

Clone: 5H4

Détail du produit anti-IFITM3 anticorps

Épitope: AA 1-133

Fonction: IFITM3 antibody

Purification: Protein A+G purification

Pureté: ≥95 % as determined by SDS-PAGE

Immunogène:

Immunogen sequence: 1-133aa

Immunogen: IFITM2/3 fusion protein

Isotype: IgG1

Information d'application

Indications d'application: WB: 1:500-1:2000, IHC: 1:20-1:200, IF: 1:10-1:100

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freeze / thaw cycles.

Stock: -20 °C

Stockage commentaire: -20°C for 12 months

Date de péremption: 12 months

Détails sur IFITM3

Antigène: IFITM3 (Interferon-Induced Transmembrane Protein 3 (IFITM3))

Autre désignation: IFITM3

Sujet:

Synonyms: Interferon-induced transmembrane protein 3|Dispanin subfamily A member 2b (DSPA2b)|Interferon-inducible protein 1-8U|IFITM3

Background: IFN-induced antiviral protein which disrupts intracellular cholesterol homeostasis. Inhibits the entry of viruses to the host cell cytoplasm by preventing viral fusion with cholesterol depleted endosomes. May inactivate new enveloped viruses which buds out of the infected cell, by letting them go out with a cholesterol depleted membrane. Active against multiple viruses, including influenza A virus, SARS coronavirus(SARS-CoV), Marburg virus(MARV) and Ebola virus(EBOV), Dengue virus(DNV), West Nile virus(WNV), human immunodeficiency virus type 1(HIV-1) and vesicular stomatitis virus(VSV). Can inhibit: influenza virus hemagglutinin protein-mediated viral entry, MARV and EBOV GP1,2-mediated viral entry, SARS-CoV S protein-mediated viral entry and VSV G protein-mediated viral entry. Plays a critical role in the structural stability and function of vacuolar ATPase(v-ATPase). Establishes physical contact with the v-ATPase of endosomes which is critical for proper clathrin localization and is also required for the function of the v-ATPase to lower the pH in phagocytic endosomes thus establishing an antiviral state.This antibody recognizes both IFITM2 and IFITM3.

Poids moléculaire: 14 kDa

ID gène: 10410

UniProt: Q01628