KEAP1 anticorps (AA 350-624)

N° du produit ABIN7115610

Cet anticorps anti-KEAP1 est un anticorps Souris Monoclonal détectant KEAP1 dans WB, ELISA, IHC et IF. Adapté pour Humain, Souris et Rat.

Aperçu rapide pour KEAP1 anticorps (AA 350-624) (ABIN7115610)

Antigène: KEAP1 (Kelch-Like ECH-Associated Protein 1 (KEAP1))

Reactivité: Humain, Souris, Rat

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp KEAP1 est non-conjugé

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF)

Clone: 9E2

Détail du produit anti-KEAP1 anticorps

Épitope: AA 350-624

Fonction: KEAP1 antibody

Purification: Protein A+G purification

Pureté: ≥95 % as determined by SDS-PAGE

Immunogène:

Immunogen sequence: 350-624aa

Immunogen: kelch-like ECH-associated protein 1

Isotype: IgG2a

Information d'application

Indications d'application: WB: 1:500-1:1000, IHC: 1:50-1:500, IF: 1:10-1:100

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freeze / thaw cycles.

Stock: -20 °C

Stockage commentaire: -20°C for 12 months

Date de péremption: 12 months

Détails sur KEAP1

Antigène: KEAP1 (Kelch-Like ECH-Associated Protein 1 (KEAP1))

Autre désignation: KEAP1

Sujet:

Synonyms: Kelch-like ECH-associated protein 1|Cytosolic inhibitor of Nrf2 (INrf2)|Kelch-like protein 19|KEAP1|INRF2|KIAA0132|KLHL19

Background: Acts as a substrate adapter protein for the E3 ubiquitin ligase complex formed by CUL3 and RBX1 and targets NFE2L2/NRF2 for ubiquitination and degradation by the proteasome, thus resulting in the suppression of its transcriptional activity and the repression of antioxidant response element-mediated detoxifying enzyme gene expression. Retains NFE2L2/NRF2 and may also retain BPTF in the cytosol. Targets PGAM5 for ubiquitination and degradation by the proteasome.

Poids moléculaire: 55-70 kDa

ID gène: 9817

UniProt: Q14145

Pathways: Maintenance of Protein Location