KIF7 anticorps (AA 662-782)

N° du produit ABIN7115710

Cet anticorps Lapin Polyclonal détecte spécifiquement KIF7 dans WB, ELISA et IP. Il présente une réactivité envers Humain.

Aperçu rapide pour KIF7 anticorps (AA 662-782) (ABIN7115710)

Antigène: KIF7 (Kinesin Family Member 7 (KIF7))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp KIF7 est non-conjugé

Application: Western Blotting (WB), ELISA, Immunoprecipitation (IP)

Détail du produit anti-KIF7 anticorps

Épitope: AA 662-782

Fonction: KIF7 antibody

Purification: Immunogen affinity purified

Pureté: ≥95 % as determined by SDS-PAGE

Immunogène:

Immunogen sequence: 662-782aa

Immunogen: kinesin family member 7

Isotype: IgG

Information d'application

Indications d'application: WB: 1:500-1:2000, IP: 1:500-1:1000

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freeze / thaw cycles.

Stock: -20 °C

Stockage commentaire: -20°C for 12 months

Date de péremption: 12 months

Détails sur KIF7

Antigène: KIF7 (Kinesin Family Member 7 (KIF7))

Autre désignation: KIF7

Sujet:

Synonyms: Kinesin-like protein KIF7|KIF7

Background: Essential for hedgehog signaling regulation: acts as both a negative and positive regulator of sonic hedgehog(Shh) and Indian hedgehog(Ihh) pathways, acting downstream of SMO, through both SUFU-dependent and-independent mechanisms(PubMed:21633164). Involved in the regulation of microtubular dynamics. Required for proper organization of the ciliary tip and control of ciliary localization of SUFU-GLI2 complexes(By similarity). Required for localization of GLI3 to cilia in response to Shh. Negatively regulates Shh signaling by preventing inappropriate activation of the transcriptional activator GLI2 in the absence of ligand. Positively regulates Shh signaling by preventing the processing of the transcription factor GLI3 into its repressor form. In keratinocytes, promotes the dissociation of SUFU-GLI2 complexes, GLI2 nuclear translocation and Shh signaling activation(By similarity). Involved in the regulation of epidermal differentiation and chondrocyte development(By similarity).

Poids moléculaire: 150 kDa

ID gène: 374654

UniProt: Q2M1P5

Pathways: Signalisation Hedgehog