KISS1 anticorps (AA 124-138)

N° du produit ABIN7115721

Cet anticorps anti-KISS1 est un anticorps Lapin Polyclonal détectant KISS1 dans WB, IHC, ELISA et IF. Adapté pour Humain et Souris.

Aperçu rapide pour KISS1 anticorps (AA 124-138) (ABIN7115721)

Antigène: KISS1 (KiSS-1 Metastasis-Suppressor (KISS1))

Reactivité: Humain, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp KISS1 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC), ELISA, Immunofluorescence (IF)

Détail du produit anti-KISS1 anticorps

Épitope: AA 124-138

Fonction: KISS1 antibody

Purification: Immunogen affinity purified

Pureté: ≥95 % as determined by SDS-PAGE

Immunogène:

Immunogen sequence: A synthetic peptide,124-138aa

Immunogen: KiSS-1 metastasis-suppressor

Isotype: IgG

Information d'application

Indications d'application: WB: 1:500 - 1:2000, IHC: 1:50 - 1:200, IF: 1:50 - 1:200

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freeze / thaw cycles.

Stock: -20 °C

Stockage commentaire: -20°C for 12 months

Date de péremption: 12 months

Détails sur KISS1

Antigène: KISS1 (KiSS-1 Metastasis-Suppressor (KISS1))

Autre désignation: KISS1

Sujet:

Synonyms: Metastasis-suppressor KiSS-1|Kisspeptin-1|Metastin Alternative names: Kisspeptin-54|Kisspeptin-14|Kisspeptin-13|Kisspeptin-10|KISS1

Background: Metastasis suppressor protein in malignant melanomas and in some breast cancers. May regulate events downstream of cell-matrix adhesion, perhaps involving cytoskeletal reorganization. Generates a C-terminally amidated peptide, metastin which functions as the endogenous ligand of the G-protein coupled receptor GPR54. Activation of the receptor inhibits cell proliferation and cell migration, key characteristics of tumor metastasis. Kp-10 is a decapeptide derived from the primary translation product, isolated in conditioned medium of first trimester trophoblast. Kp-10, but not other kisspeptins, increased intracellular Ca(2+) levels in isolated first trimester trophoblasts. Kp-10 is a paracrine/endocrine regulator in fine-tuning trophoblast invasion generated by the trophoblast itself. The receptor is also essential for normal gonadotropin-released hormone physiology and for puberty. The hypothalamic KiSS1/GPR54 system is a pivotal factor in central regulation of the gonadotropic axis at puberty and in adulthood.

Poids moléculaire: 16-20 kDa

ID gène: 3814

UniProt: Q15726

Pathways: Positive Regulation of Peptide Hormone Secretion