MAML1 anticorps

N° du produit ABIN7116076

Cet anticorps Lapin Polyclonal détecte spécifiquement MAML1 dans ELISA et WB. Il présente une réactivité envers Humain, Souris et Rat.

Aperçu rapide pour MAML1 anticorps (ABIN7116076)

Antigène: MAML1 (Mastermind-Like 1 (MAML1))

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp MAML1 est non-conjugé

Application: ELISA, Western Blotting (WB)

Détail du produit anti-MAML1 anticorps

Fonction: MAML1 antibody

Purification: Immunogen affinity purified

Pureté: ≥95 % as determined by SDS-PAGE

Immunogène: mastermind-like 1(Drosophila)

Isotype: IgG

Information d'application

Indications d'application: WB: 1:500-1:2000

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freeze / thaw cycles.

Stock: -20 °C

Stockage commentaire: -20°C for 12 months

Date de péremption: 12 months

Détails sur MAML1

Antigène: MAML1 (Mastermind-Like 1 (MAML1))

Autre désignation: MAML1

Sujet:

Synonyms: Mastermind-like protein 1 (Mam-1)|MAML1|KIAA0200

Background: Acts as a transcriptional coactivator for NOTCH proteins. Has been shown to amplify NOTCH-induced transcription of HES1. Enhances phosphorylation and proteolytic turnover of the NOTCH intracellular domain in the nucleus through interaction with CDK8. Binds to CREBBP/CBP which promotes nucleosome acetylation at NOTCH enhancers and activates transcription. Induces phosphorylation and localization of CREBBP to nuclear foci. Plays a role in hematopoietic development by regulating NOTCH-mediated lymphoid cell fate decisions.

Poids moléculaire: 108-120 kDa

ID gène: 9794

UniProt: Q92585

Pathways: Signalisation Notch, Regulation of Muscle Cell Differentiation, Skeletal Muscle Fiber Development