MUL1 anticorps

N° du produit ABIN7116330

Cet anticorps anti-MUL1 est un anticorps Lapin Polyclonal détectant MUL1 dans WB, ELISA et IHC. Adapté pour Humain, Souris et Rat.

Aperçu rapide pour MUL1 anticorps (ABIN7116330)

Antigène: MUL1 (Mitochondrial E3 Ubiquitin Protein Ligase 1 (MUL1))

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp MUL1 est non-conjugé

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC)

Détail du produit anti-MUL1 anticorps

Fonction: MUL1 antibody

Purification: Immunogen affinity purified

Pureté: ≥95 % as determined by SDS-PAGE

Immunogène: mitochondrial E3 ubiquitin ligase 1

Isotype: IgG

Information d'application

Indications d'application: WB: 1:500-1:2000, IHC: 1:20-1:200

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freeze / thaw cycles.

Stock: -20 °C

Stockage commentaire: -20°C for 12 months

Date de péremption: 12 months

Détails sur MUL1

Antigène: MUL1 (Mitochondrial E3 Ubiquitin Protein Ligase 1 (MUL1))

Autre désignation: MUL1

Sujet:

Synonyms: Mitochondrial ubiquitin ligase activator of NFKB 1|E3 SUMO-protein ligase MUL1|E3 ubiquitin-protein ligase MUL1|Growth inhibition and death E3 ligase|Mitochondrial-anchored protein ligase|Protein Hades|Putative NF-kappa-B-activating protein 266|RING finger protein 218|RING-type E3 ubiquitin transferase NFKB 1|MUL1|C1orf166|GIDE|MAPL|MULAN|RNF218

Background: Exhibits weak E3 ubiquitin-protein ligase activity. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates. Can ubiquitinate AKT1 preferentially at 'Lys-284' involving 'Lys-48'-linked polyubiquitination and seems to be involved in regulation of Akt signaling by targeting phosphorylated Akt to proteosomal degradation. Proposed to preferentially act as a SUMO E3 ligase at physiological concentrations. Plays a role in the control of mitochondrial morphology. Promotes mitochondrial fragmentation and influences mitochondrial localization. The function may implicate its ability to sumoylate DNM1L. Inhibits cell growth. When overexpressed, activates JNK through MAP3K7/TAK1 and induces caspase-dependent apoptosis. Involved in the modulation of innate immune defense against viruses by inhibiting DDX58-dependent antiviral response. Can mediate DDX58 sumoylation and disrupt its polyubiquitination.

Poids moléculaire: 35 kDa

ID gène: 79594

UniProt: Q969V5

Pathways: Positive Regulation of Endopeptidase Activity