MCC anticorps

N° du produit ABIN7116539

L’anticorps Lapin Polyclonal anti-MCC a été validé pour ELISA, WB, IHC, IP et IF. Il convient pour détecter MCC dans des échantillons de Humain et Souris.

Aperçu rapide pour MCC anticorps (ABIN7116539)

Antigène: MCC (Mutated in Colorectal Cancers (MCC))

Reactivité: Humain, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp MCC est non-conjugé

Application: ELISA, Western Blotting (WB), Immunohistochemistry (IHC), Immunoprecipitation (IP), Immunofluorescence (IF)

Détail du produit anti-MCC anticorps

Fonction: MCC antibody

Purification: Immunogen affinity purified

Pureté: ≥95 % as determined by SDS-PAGE

Immunogène: mutated in colorectal cancers

Isotype: IgG

Information d'application

Indications d'application: WB: 1:500-1:2000, IP: 1:200-1:1000, IHC: 1:20-1:200, IF: 1:20-1:200

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freeze / thaw cycles.

Stock: -20 °C

Stockage commentaire: -20°C for 12 months

Date de péremption: 12 months

Détails sur MCC

Antigène: MCC (Mutated in Colorectal Cancers (MCC))

Autre désignation: MCC

Sujet:

Synonyms: Colorectal mutant cancer protein (Protein MCC)|MCC

Background: Candidate for the putative colorectal tumor suppressor gene located at 5q21. Suppresses cell proliferation and the Wnt/b-catenin pathway in colorectal cancer cells. Inhibits DNA binding of b-catenin/TCF/LEF transcription factors. Involved in cell migration independently of RAC1, CDC42 and p21-activated kinase(PAK) activation(PubMed:18591935, PubMed:19555689, PubMed:22480440). Represses the beta-catenin pathway(canonical Wnt signaling pathway) in a CCAR2-dependent manner by sequestering CCAR2 to the cytoplasm, thereby impairing its ability to inhibit SIRT1 which is involved in the deacetylation and negative regulation of beta-catenin(CTNB1) transcriptional activity(PubMed:24824780).

Poids moléculaire: 98 kDa,113-118 kDa

ID gène: 4163

UniProt: P23508