MCC anticorps (AA 479-611)

N° du produit ABIN7148294

Détail du produit anti-MCC anticorps

Antigène: MCC (Mutated in Colorectal Cancers (MCC))

Épitope: AA 479-611

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp MCC est non-conjugé

Application: ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF)

Réactivité croisée: Humain

Purification: >95%, Protein G purified

Immunogène: Recombinant Human Colorectal mutant cancer protein (479-611AA)

Isotype: IgG

Information d'application

Indications d'application: Recommended dilution: IHC:1:500-1:1000, IF:1:50-1:200,

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C,-80 °C

Stockage commentaire: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Détails sur MCC

Antigène: MCC (Mutated in Colorectal Cancers (MCC))

Autre désignation: MCC (MCC Produits)

Synonymes: anticorps MCC, anticorps mcc1, anticorps MCC1, anticorps D18Ertd451e, anticorps E330037C19, anticorps RGD1561988, anticorps mutated in colorectal cancers, anticorps MCC, anticorps mcc, anticorps Mcc

Sujet:

Background: Candidate for the putative colorectal tumor suppressor gene located at 5q21. Suppresses cell proliferation and the Wnt/b-catenin pathway in colorectal cancer cells. Inhibits DNA binding of b-catenin/TCF/LEF transcription factors. Involved in cell migration independently of RAC1, CDC42 and p21-activated kinase (PAK) activation (PubMed:18591935, PubMed:19555689, PubMed:22480440). Represses the beta-catenin pathway (canonical Wnt signaling pathway) in a CCAR2-dependent manner by sequestering CCAR2 to the cytoplasm, thereby impairing its ability to inhibit SIRT1 which is involved in the deacetylation and negative regulation of beta-catenin (CTNB1) transcriptional activity (PubMed:24824780).

Aliases: Colorectal mutant cancer protein antibody, CRCM_HUMAN antibody, DKFZp762O1615 antibody, FLJ38893 antibody, FLJ46755 antibody, MCC 1 antibody, MCC antibody, MCC1 antibody, Mutated in colorectal cancers antibody, Protein MCC antibody

UniProt: P23508