NUMBL anticorps

N° du produit ABIN7117092

Cet anticorps anti-NUMBL est un anticorps Souris Monoclonal détectant NUMBL dans WB, ELISA et IHC. Adapté pour Humain.

Aperçu rapide pour NUMBL anticorps (ABIN7117092)

Antigène: NUMBL (Numb Homolog (Drosophila)-Like (NUMBL))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp NUMBL est non-conjugé

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC)

Clone: 8E0

Détail du produit anti-NUMBL anticorps

Fonction: NUMBL antibody

Purification: Protein A+G purification

Pureté: ≥95 % as determined by SDS-PAGE

Immunogène: numb homolog(Drosophila)-like

Isotype: IgG2a

Information d'application

Indications d'application: WB: 1:500-1:2000, IHC: 1:20-1:200

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freeze / thaw cycles.

Stock: -20 °C

Stockage commentaire: -20°C for 12 months

Date de péremption: 12 months

Détails sur NUMBL

Antigène: NUMBL (Numb Homolog (Drosophila)-Like (NUMBL))

Autre désignation: NUMBL

Sujet:

Synonyms: Numb-like protein|Numb-related protein (Numb-R)|NUMBL

Background: Plays a role in the process of neurogenesis. Required throughout embryonic neurogenesis to maintain neural progenitor cells, also called radial glial cells(RGCs), by allowing their daughter cells to choose progenitor over neuronal cell fate. Not required for the proliferation of neural progenitor cells before the onset of embryonic neurogenesis. Also required postnatally in the subventricular zone(SVZ) neurogenesis by regulating SVZ neuroblasts survival and ependymal wall integrity. Negative regulator of NF-kappa-B signaling pathway. The inhibition of NF-kappa-B activation is mediated at least in part, by preventing MAP3K7IP2 to interact with polyubiquitin chains of TRAF6 and RIPK1 and by stimulating the 'Lys-48'-linked polyubiquitination and degradation of TRAF6 in cortical neurons.

Poids moléculaire: 70 kDa

ID gène: 9253

UniProt: Q9Y6R0

Pathways: Cell-Cell Junction Organization