PARP3 anticorps

N° du produit ABIN7117630

Cet anticorps Lapin Polyclonal détecte spécifiquement PARP3 dans ELISA, WB, IHC et IF. Il présente une réactivité envers Humain, Souris et Rat.

Aperçu rapide pour PARP3 anticorps (ABIN7117630)

Antigène: PARP3 (Poly (ADP-Ribose) Polymerase Family, Member 3 (PARP3))

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp PARP3 est non-conjugé

Application: ELISA, Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)

Détail du produit anti-PARP3 anticorps

Fonction: PARP3 antibody

Purification: Immunogen affinity purified

Pureté: ≥95 % as determined by SDS-PAGE

Immunogène: poly(ADP-ribose) polymerase family, member 3

Isotype: IgG

Information d'application

Indications d'application: WB: 1:500-1:2000, IHC: 1:20-1:200, IF: 1:20-1:200

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freeze / thaw cycles.

Stock: -20 °C

Stockage commentaire: -20°C for 12 months

Date de péremption: 12 months

Détails sur PARP3

Antigène: PARP3 (Poly (ADP-Ribose) Polymerase Family, Member 3 (PARP3))

Autre désignation: PARP3

Sujet:

Synonyms: Protein mono-ADP-ribosyltransferase PARP3|ADP-ribosyltransferase diphtheria toxin-like 3 (ARTD3)|DNA ADP-ribosyltransferase PARP3|IRT1|NAD(+) ADP-ribosyltransferase 3 (ADPRT-3)|Poly [ADP-ribose] polymerase 3 (PARP-3, hPARP-3)|Poly[ADP-ribose] synthase 3 (pADPRT-3)|PARP3|ADPRT3|ADPRTL3

Background: Involved in the base excision repair(BER) pathway, by catalyzing the poly(ADP-ribosyl)ation of a limited number of acceptor proteins involved in chromatin architecture and in DNA metabolism. This modification follows DNA damages and appears as an obligatory step in a detection/signaling pathway leading to the reparation of DNA strand breaks. May link the DNA damage surveillance network to the mitotic fidelity checkpoint. Negatively influences the G1/S cell cycle progression without interfering with centrosome duplication. Binds DNA. May be involved in the regulation of PRC2 and PRC3 complex-dependent gene silencing.

Poids moléculaire: 60-62 kDa

ID gène: 10039

UniProt: Q9Y6F1