PMEPA1 anticorps

N° du produit ABIN7117874

L’anticorps anti-PMEPA1 Polyclonal Lapin est utilisé pour la détection de PMEPA1 dans des échantillons de Humain, Souris et Rat. Il a été validé pour IHC, WB, ELISA et IF.

Aperçu rapide pour PMEPA1 anticorps (ABIN7117874)

Antigène: PMEPA1 (Prostate Transmembrane Protein, Androgen Induced 1 (PMEPA1))

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp PMEPA1 est non-conjugé

Application: Immunohistochemistry (IHC), Western Blotting (WB), ELISA, Immunofluorescence (IF)

Détail du produit anti-PMEPA1 anticorps

Fonction: PMEPA1 antibody

Purification: Immunogen affinity purified

Pureté: ≥95 % as determined by SDS-PAGE

Immunogène: prostate transmembrane protein, androgen induced 1

Isotype: IgG

Information d'application

Indications d'application: WB: 1:500-1:2000, IHC: 1:20-1:200, IF: 1:20-1:200

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freeze / thaw cycles.

Stock: -20 °C

Stockage commentaire: -20°C for 12 months

Date de péremption: 12 months

Détails sur PMEPA1

Antigène: PMEPA1 (Prostate Transmembrane Protein, Androgen Induced 1 (PMEPA1))

Autre désignation: PMEPA1

Sujet:

Synonyms: Protein TMEPAI|Prostate transmembrane protein androgen induced 1|Solid tumor-associated 1 protein|Transmembrane prostate androgen-induced protein|PMEPA1|STAG1|TMEPAI

Background: Functions as a negative regulator of TGF-beta signaling and thereby probably plays a role in cell proliferation, differentiation, apoptosis, motility, extracellular matrix production and immunosuppression. In the canonical TGF-beta pathway, ZFYVE9/SARA recruits the intracellular signal transducer and transcriptional modulators SMAD2 and SMAD3 to the TGF-beta receptor. Phosphorylated by the receptor, SMAD2 and SMAD3 then form a heteromeric complex with SMAD4 that translocates to the nucleus to regulate transcription. Through interaction with SMAD2 and SMAD3, LDLRAD4 may compete with ZFYVE9 and SMAD4 and prevent propagation of the intracellular signal(PubMed:20129061, PubMed:24627487). Also involved in down-regulation of the androgen receptor(AR), enhancing ubiquitination and proteasome-mediated degradation of AR, probably by recruiting NEDD4(PubMed:18703514).

Poids moléculaire: 32 kDa

ID gène: 56937

UniProt: Q969W9

Pathways: Intracellular Steroid Hormone Receptor Signaling Pathway