PRMT1 anticorps

N° du produit ABIN7117926

Cet anticorps anti-PRMT1 est un anticorps Lapin Polyclonal détectant PRMT1 dans WB, ELISA et IHC. Adapté pour Humain, Souris et Rat.

Aperçu rapide pour PRMT1 anticorps (ABIN7117926)

Antigène: PRMT1 (Protein Arginine Methyltransferase 1 (PRMT1))

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp PRMT1 est non-conjugé

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC)

Détail du produit anti-PRMT1 anticorps

Fonction: PRMT1 antibody

Purification: Immunogen affinity purified

Pureté: ≥95 % as determined by SDS-PAGE

Immunogène: protein arginine methyltransferase 1

Isotype: IgG

Information d'application

Indications d'application: WB: 1:500-1:2000, IHC: 1:20-1:200

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freeze / thaw cycles.

Stock: -20 °C

Stockage commentaire: -20°C for 12 months

Date de péremption: 12 months

Détails sur PRMT1

Antigène: PRMT1 (Protein Arginine Methyltransferase 1 (PRMT1))

Autre désignation: PRMT1

Sujet:

Synonyms: Protein arginine N-methyltransferase 1|Histone-arginine N-methyltransferase PRMT1|Interferon receptor 1-bound protein 4|PRMT1|HMT2|HRMT1L2|IR1B4

Background: Arginine methyltransferase that methylates(mono and asymmetric dimethylation) the guanidino nitrogens of arginyl residues present in proteins such as ESR1, histone H2, H3 and H4, PIAS1, HNRNPA1, HNRNPD, NFATC2IP, SUPT5H, TAF15 and EWS. Constitutes the main enzyme that mediates monomethylation and asymmetric dimethylation of histone H4 'Arg-4'(H4R3me1 and H4R3me2a, respectively), a specific tag for epigenetic transcriptional activation. Together with dimethylated PIAS1, represses STAT1 transcriptional activity, in the late phase of interferon gamma(IFN-gamma) signaling. May be involved in the regulation of TAF15 transcriptional activity, act as an activator of estrogen receptor(ER)-mediated transactivation, play a key role in neurite outgrowth and act as a negative regulator of megakaryocytic differentiation, by modulating p38 MAPK pathway. Methylates FOXO1 and retains it in the nucleus increasing its transcriptional activity. Methylates CHTOP and this methylation is critical for its 5-hydroxymethylcytosine(5hmC)-binding activity(PubMed:25284789). Methylates H4R3 in genes involved in glioblastomagenesis in a CHTOP-and/or TET1-dependent manner(PubMed:25284789).

Poids moléculaire: 40-42 kDa

ID gène: 3276

UniProt: Q99873