anticorps PICK, anticorps PRKCABP, anticorps Prkcabp, anticorps prkcabp, anticorps MGC131295, anticorps PICK1, anticorps DKFZp470L2127, anticorps protein interacting with PRKCA 1, anticorps protein interacting with C kinase 1, anticorps protein interacting with PRKCA 1 L homeolog, anticorps PICK1, anticorps Pick1, anticorps pick1, anticorps pick1.L
Sujet
Synonyms:PRKCABP Background:Probable adapter protein that bind to and organize the subcellular localization of a variety of membrane proteins containing some PDZ recognition sequence. Involved in the clustering of various receptors, possibly by acting at the receptor internalization level. Plays a role in synaptic plasticity by regulating the trafficking and internalization of AMPA receptors. May be regulated upon PRKCA activation. May regulate ASIC1/ASIC3 channel. Regulates actin polymerization by inhibiting the actin-nucleating activity of the Arp2/3 complex, the function is competetive with nucleation promoting factors and is linked to neuronal morphology regulation and AMPA receptor(AMPAR) endocytosis. Via interaction with the Arp2/3 complex involved in regulation of synaptic plasicity of excitatory synapses and required for spine shrinkage during long-term depression(LTD). Involved in regulation of astrocyte morphology, antagonistic to Arp2/3 complex activator WASL/N-WASP function.