PPP1CC anticorps

N° du produit ABIN7117989

Cet anticorps anti-PPP1CC est un anticorps Lapin Polyclonal détectant PPP1CC dans WB, ELISA, IHC, IF et IP. Adapté pour Humain, Souris et Rat.

Aperçu rapide pour PPP1CC anticorps (ABIN7117989)

Antigène: PPP1CC (Protein Phosphatase 1, Catalytic Subunit, gamma Isoform (PPP1CC))

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp PPP1CC est non-conjugé

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF), Immunoprecipitation (IP)

Détail du produit anti-PPP1CC anticorps

Fonction: PPP1CC antibody

Purification: Immunogen affinity purified

Pureté: ≥95 % as determined by SDS-PAGE

Immunogène: protein phosphatase 1, catalytic subunit, gamma isoform

Isotype: IgG

Information d'application

Indications d'application: WB: 1:500-1:2000, IP: 1:200-1:1000, IHC: 1:20-1:200, IF: 1:20-1:200

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freeze / thaw cycles.

Stock: -20 °C

Stockage commentaire: -20°C for 12 months

Date de péremption: 12 months

Détails sur PPP1CC

Antigène: PPP1CC (Protein Phosphatase 1, Catalytic Subunit, gamma Isoform (PPP1CC))

Autre désignation: PPP1CC

Sujet:

Synonyms: Serine/threonine-protein phosphatase PP1-gamma catalytic subunit (PP-1G)|Protein phosphatase 1C catalytic subunit|PPP1CC

Background: Protein phosphatase that associates with over 200 regulatory proteins to form highly specific holoenzymes which dephosphorylate hundreds of biological targets. Protein phosphatase 1(PP1) is essential for cell division, and participates in the regulation of glycogen metabolism, muscle contractility and protein synthesis. Dephosphorylates RPS6KB1. Involved in regulation of ionic conductances and long-term synaptic plasticity. May play an important role in dephosphorylating substrates such as the postsynaptic density-associated Ca(2+)/calmodulin dependent protein kinase II. Component of the PTW/PP1 phosphatase complex, which plays a role in the control of chromatin structure and cell cycle progression during the transition from mitosis into interphase. In balance with CSNK1D and CSNK1E, determines the circadian period length, through the regulation of the speed and rhythmicity of PER1 and PER2 phosphorylation. May dephosphorylate CSNK1D and CSNK1E. Dephosphorylates the 'Ser-418' residue of FOXP3 in regulatory T-cells(Treg) from patients with rheumatoid arthritis, thereby inactivating FOXP3 and rendering Treg cells functionally defective(PubMed:23396208).

Poids moléculaire: 35 kDa

ID gène: 5501

UniProt: P36873

Pathways: Cellular Glucan Metabolic Process, Lipid Metabolism