PPP1R9B anticorps

N° du produit ABIN7118007

Cet anticorps anti-PPP1R9B est un anticorps Lapin Polyclonal détectant PPP1R9B dans WB, ELISA, IHC et IP. Adapté pour Humain, Rat et Souris.

Aperçu rapide pour PPP1R9B anticorps (ABIN7118007)

Antigène: PPP1R9B (Protein Phosphatase 1, Regulatory Subunit 9B, Spinophilin (PPP1R9B))

Reactivité: Humain, Rat, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp PPP1R9B est non-conjugé

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunoprecipitation (IP)

Détail du produit anti-PPP1R9B anticorps

Fonction: PPP1R9B antibody

Purification: Immunogen affinity purified

Pureté: ≥95 % as determined by SDS-PAGE

Immunogène: protein phosphatase 1, regulatory(inhibitor) subunit 9B

Isotype: IgG

Information d'application

Indications d'application: WB: 1:500-1:2000, IP: 1:200-1:1000, IHC: 1:20-1:200

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freeze / thaw cycles.

Stock: -20 °C

Stockage commentaire: -20°C for 12 months

Date de péremption: 12 months

Détails sur PPP1R9B

Antigène: PPP1R9B (Protein Phosphatase 1, Regulatory Subunit 9B, Spinophilin (PPP1R9B))

Autre désignation: PPP1R9B

Sujet:

Synonyms: Neurabin-2|Neurabin-II|Protein phosphatase 1 regulatory subunit 9B|Spinophilin|PPP1R9B|PPP1R6

Background: Seems to act as a scaffold protein in multiple signaling pathways. Modulates excitatory synaptic transmission and dendritic spine morphology. Binds to actin filaments(F-actin) and shows cross-linking activity. Binds along the sides of the F-actin. May play an important role in linking the actin cytoskeleton to the plasma membrane at the synaptic junction. Believed to target protein phosphatase 1/PP1 to dendritic spines, which are rich in F-actin, and regulates its specificity toward ion channels and other substrates, such as AMPA-type and NMDA-type glutamate receptors. Plays a role in regulation of G-protein coupled receptor signaling, including dopamine D2 receptors and alpha-adrenergic receptors. May establish a signaling complex for dopaminergic neurotransmission through D2 receptors by linking receptors downstream signaling molecules and the actin cytoskeleton. Binds to ADRA1B and RGS2 and mediates regulation of ADRA1B signaling. May confer to Rac signaling specificity by binding to both, RacGEFs and Rac effector proteins. Probably regulates p70 S6 kinase activity by forming a complex with TIAM1(By similarity). Required for hepatocyte growth factor(HGF)-induced cell migration.

Poids moléculaire: 120-130 kDa

ID gène: 84687

UniProt: Q96SB3

Pathways: Regulation of G-Protein Coupled Receptor Protein Signaling