PP5 anticorps

N° du produit ABIN7118033

Détail du produit anti-PP5 anticorps

Antigène: PP5 (PPP5C) (Protein Phosphatase 5, Catalytic Subunit (PPP5C))

Reactivité: Humain, Rat, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp PP5 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC), ELISA

Purification: Immunogen affinity purified

Pureté: ≥95 % as determined by SDS-PAGE

Immunogène: protein phosphatase 5, catalytic subunit

Isotype: IgG

Information d'application

Indications d'application: WB: 1:500-1:2000, IHC: 1:20-1:200

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: -20°C for 12 months (Avoid repeated freeze / thaw cycles.)

Date de péremption: 12 months

Détails sur PP5

Antigène: PP5 (PPP5C) (Protein Phosphatase 5, Catalytic Subunit (PPP5C))

Autre désignation: PPP5C (PPP5C Produits)

Synonymes: anticorps PP5, anticorps PPP5, anticorps PPT, anticorps AU020526, anticorps pp5, anticorps MGC89961, anticorps fc83f08, anticorps im:7146608, anticorps wu:fc83f08, anticorps zgc:110801, anticorps PPP5C, anticorps protein phosphatase 5 catalytic subunit, anticorps protein phosphatase 5, catalytic subunit, anticorps protein phosphatase 5, catalytic subunit S homeolog, anticorps serine/threonine-protein phosphatase 5, anticorps PPP5C, anticorps Ppp5c, anticorps ppp5c.S, anticorps ppp5c, anticorps LOC592155, anticorps LOC100513542, anticorps LOC100564151, anticorps LOC100186268, anticorps LOC100208775

Sujet: Synonyms:PPP5 Background:Serine/threonine-protein phosphatase that dephosphorylates a myriad of proteins involved in different signaling pathways including the kinases CSNK1E, ASK1/MAP3K5, PRKDC and RAF1, the nuclear receptors NR3C1, PPARG, ESR1 and ESR2, SMAD proteins and TAU/MAPT. Implicated in wide ranging cellular processes, including apoptosis, differentiation, DNA damage response, cell survival, regulation of ion channels or circadian rhythms, in response to steroid and thyroid hormones, calcium, fatty acids, TGF-beta as well as oxidative and genotoxic stresses. Participates in the control of DNA damage response mechanisms such as checkpoint activation and DNA damage repair through, for instance, the regulation ATM/ATR-signaling and dephosphorylation of PRKDC and TP53BP1. Inhibits ASK1/MAP3K5-mediated apoptosis induced by oxidative stress. Plays a positive role in adipogenesis, mainly through the dephosphorylation and activation of PPARG transactivation function. Also dephosphorylates and inhibits the anti-adipogenic effect of NR3C1. Regulates the circadian rhythms, through the dephosphorylation and activation of CSNK1E. May modulate TGF-beta signaling pathway by the regulation of SMAD3 phosphorylation and protein expression levels. Dephosphorylates and may play a role in the regulation of TAU/MAPT. Through their dephosphorylation, may play a role in the regulation of ions channels such as KCNH2.

Poids moléculaire: 57 kDa

ID gène: 5536

UniProt: P53041