PSME3 anticorps

N° du produit ABIN7118115

Cet anticorps anti-PSME3 est un anticorps Lapin Polyclonal détectant PSME3 dans WB, IHC, ELISA, IF et IP. Adapté pour Humain, Rat et Souris.

Aperçu rapide pour PSME3 anticorps (ABIN7118115)

Antigène: PSME3

Reactivité: Humain, Rat, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp PSME3 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC), ELISA, Immunofluorescence (IF), Immunoprecipitation (IP)

Détail du produit anti-PSME3 anticorps

Fonction: PSME3 antibody

Purification: Immunogen affinity purified

Pureté: ≥95 % as determined by SDS-PAGE

Immunogène:

Immunogen sequence: 2-254

Immunogen: proteasome(prosome, macropain) activator subunit 3(PA28 gamma, Ki)

Isotype: IgG

Information d'application

Indications d'application: WB: 1:500-1:2000, IP: 1:200-1:1000, IHC: 1:20-1:200, IF: 1:20-1:200

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freeze / thaw cycles.

Stock: -20 °C

Stockage commentaire: -20°C for 12 months

Date de péremption: 12 months

Détails sur PSME3

Antigène: PSME3

Autre désignation: PSME3

Sujet:

Synonyms: Proteasome activator complex subunit 3|11S regulator complex subunit gamma (REG-gamma)|Activator of multicatalytic protease subunit 3|Ki nuclear autoantigen|Proteasome activator 28 subunit gamma (PA28g, PA28gamma)|PSME3

Background: Subunit of the 11S REG-gamma(also called PA28-gamma) proteasome regulator, a doughnut-shaped homoheptamer which associates with the proteasome. 11S REG-gamma activates the trypsin-like catalytic subunit of the proteasome but inhibits the chymotrypsin-like and postglutamyl-preferring(PGPH) subunits. Facilitates the MDM2-p53/TP53 interaction which promotes ubiquitination-and MDM2-dependent proteasomal degradation of p53/TP53, limiting its accumulation and resulting in inhibited apoptosis after DNA damage. May also be involved in cell cycle regulation. Mediates CCAR2 and CHEK2-dependent SIRT1 inhibition(PubMed:25361978).

Poids moléculaire: 30 kDa

ID gène: 10197

UniProt: P61289

Pathways: Mitotic G1-G1/S Phases, DNA Replication, Positive Regulation of Endopeptidase Activity, Hepatitis C, Synthesis of DNA