R-Spondin 3 anticorps (AA 22-272)

N° du produit ABIN7118173

Cet anticorps Lapin Polyclonal détecte spécifiquement R-Spondin 3 dans WB, ELISA et IHC. Il présente une réactivité envers Humain, Souris et Rat.

Aperçu rapide pour R-Spondin 3 anticorps (AA 22-272) (ABIN7118173)

Antigène: R-Spondin 3 (RSPO3)

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp R-Spondin 3 est non-conjugé

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC)

Détail du produit anti-R-Spondin 3 anticorps

Épitope: AA 22-272

Fonction: RSPO3 antibody

Purification: Immunogen affinity purified

Pureté: ≥95 % as determined by SDS-PAGE

Immunogène:

Immunogen sequence: 22-272aa

Immunogen: R-spondin 3 homolog

Isotype: IgG

Information d'application

Indications d'application: WB: 1:200-1:1000, IHC: 1:100-1:400

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freeze / thaw cycles.

Stock: -20 °C

Stockage commentaire: -20°C for 12 months

Date de péremption: 12 months

Détails sur R-Spondin 3

Antigène: R-Spondin 3 (RSPO3)

Autre désignation: RSPO3

Sujet:

Synonyms: R-spondin-3|Protein with TSP type-1 repeat (hPWTSR)|Roof plate-specific spondin-3 (hRspo3)|Thrombospondin type-1 domain-containing protein 2|RSPO3|PWTSR|THSD2

Background: Activator of the canonical Wnt signaling pathway by acting as a ligand for LGR4-6 receptors, which acts as a key regulator of angiogenesis. Upon binding to LGR4-6(LGR4, LGR5 or LGR6), LGR4-6 associate with phosphorylated LRP6 and frizzled receptors that are activated by extracellular Wnt receptors, triggering the canonical Wnt signaling pathway to increase expression of target genes. Also regulates the canonical Wnt/beta-catenin-dependent pathway and non-canonical Wnt signaling by acting as an inhibitor of ZNRF3, an important regulator of the Wnt signaling pathway. Acts as a ligand for frizzled FZD8 and LRP6. May negatively regulate the TGF-beta pathway(PubMed:21727895, PubMed:21909076, PubMed:22615920). Acts as a key regulator of angiogenesis by controlling vascular stability and pruning: acts by activating the non-canonical Wnt signaling pathway in endothelial cells(By similarity).

Poids moléculaire: 40 kDa

ID gène: 84870

UniProt: Q9BXY4