REST anticorps

N° du produit ABIN7118333

L’anticorps Lapin Polyclonal anti-REST a été validé pour WB, ELISA et IP. Il convient pour détecter REST dans des échantillons de Humain et Rat.

Aperçu rapide pour REST anticorps (ABIN7118333)

Antigène: REST (RE1-Silencing Transcription Factor (REST))

Reactivité: Humain, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp REST est non-conjugé

Application: Western Blotting (WB), ELISA, Immunoprecipitation (IP)

Détail du produit anti-REST anticorps

Fonction: REST antibody

Purification: Immunogen affinity purified

Pureté: ≥95 % as determined by SDS-PAGE

Immunogène: RE1-silencing transcription factor

Isotype: IgG

Information d'application

Indications d'application: WB: 1:500-1:1000, IP: 1:500-1:2000

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freeze / thaw cycles.

Stock: -20 °C

Stockage commentaire: -20°C for 12 months

Date de péremption: 12 months

Détails sur REST

Antigène: REST (RE1-Silencing Transcription Factor (REST))

Autre désignation: REST

Sujet:

Synonyms: RE1-silencing transcription factor|Neural-restrictive silencer factor|X2 box repressor|REST|NRSF|XBR

Background: Transcriptional repressor which binds neuron-restrictive silencer element(NRSE) and represses neuronal gene transcription in non-neuronal cells. Restricts the expression of neuronal genes by associating with two distinct corepressors, mSin3 and CoREST, which in turn recruit histone deacetylase to the promoters of REST-regulated genes. Mediates repression by recruiting the BHC complex at RE1/NRSE sites which acts by deacetylating and demethylating specific sites on histones, thereby acting as a chromatin modifier. Transcriptional repression by REST-CDYL via the recruitment of histone methyltransferase EHMT2 may be important in transformation suppression.

Poids moléculaire: 122 kDa, 200kd

ID gène: 5978

UniProt: Q13127

Pathways: Negative Regulation of Hormone Secretion, Regulation of Hormone Metabolic Process, Regulation of Hormone Biosynthetic Process, Chromatin Binding, Positive Regulation of Endopeptidase Activity