RBPJ anticorps

N° du produit ABIN7118354

L’anticorps anti-RBPJ Monoclonal Souris est utilisé pour la détection de RBPJ dans des échantillons de Humain. Il a été validé pour WB et ELISA.

Aperçu rapide pour RBPJ anticorps (ABIN7118354)

Antigène: RBPJ (Recombination Signal Binding Protein For Immunoglobulin kappa J Region (RBPJ))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp RBPJ est non-conjugé

Application: Western Blotting (WB), ELISA

Clone: 2A10

Détail du produit anti-RBPJ anticorps

Fonction: RBPJ antibody

Purification: Protein A+G purification

Pureté: ≥95 % as determined by SDS-PAGE

Immunogène: recombination signal binding protein for immunoglobulin kappa J region

Isotype: IgG1

Information d'application

Indications d'application: WB: 1:500-1:2000

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freeze / thaw cycles.

Stock: -20 °C

Stockage commentaire: -20°C for 12 months

Date de péremption: 12 months

Détails sur RBPJ

Antigène: RBPJ (Recombination Signal Binding Protein For Immunoglobulin kappa J Region (RBPJ))

Autre désignation: RBPJ

Sujet:

Synonyms: Recombining binding protein suppressor of hairless|CBF-1|J kappa-recombination signal-binding protein|RBP-J kappa (RBP-J, RBP-JK)|Renal carcinoma antigen NY-REN-30|RBPJ|IGKJRB|IGKJRB1|RBPJK|RBPSUH

Background: Transcriptional regulator that plays a central role in Notch signaling, a signaling pathway involved in cell-cell communication that regulates a broad spectrum of cell-fate determinations. Acts as a transcriptional repressor when it is not associated with Notch proteins. When associated with some NICD product of Notch proteins(Notch intracellular domain), it acts as a transcriptional activator that activates transcription of Notch target genes. Probably represses or activates transcription via the recruitment of chromatin remodeling complexes containing histone deacetylase or histone acetylase proteins, respectively. Specifically binds to the immunoglobulin kappa-type J segment recombination signal sequence. Binds specifically to methylated DNA. Binds to the oxygen responsive element of COX4I2 and activates its transcription under hypoxia conditions(4 % oxygen)(PubMed:23303788).

Poids moléculaire: 60 kDa

ID gène: 3516

UniProt: Q06330

Pathways: Signalisation Notch, Stem Cell Maintenance, Smooth Muscle Cell Migration