TRIM27 anticorps (AA 200-513)

N° du produit ABIN7118412

Cet anticorps anti-TRIM27 est un anticorps Lapin Polyclonal détectant TRIM27 dans WB, IHC, ELISA, IF et IP. Adapté pour Humain, Souris et Rat.

Aperçu rapide pour TRIM27 anticorps (AA 200-513) (ABIN7118412)

Antigène: TRIM27 (Tripartite Motif Containing 27 (TRIM27))

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp TRIM27 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC), ELISA, Immunofluorescence (IF), Immunoprecipitation (IP)

Détail du produit anti-TRIM27 anticorps

Épitope: AA 200-513

Fonction: TRIM27 antibody

Purification: Immunogen affinity purified

Pureté: ≥95 % as determined by SDS-PAGE

Immunogène:

Immunogen sequence: 200-513aa

Immunogen: tripartite motif-containing 27

Isotype: IgG

Information d'application

Indications d'application: WB: 1:500-1:2000, IP: 1:500-1:5000, IHC: 1:20-1:200, IF: 1:20-1:200

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freeze / thaw cycles.

Stock: -20 °C

Stockage commentaire: -20°C for 12 months

Date de péremption: 12 months

Détails sur TRIM27

Antigène: TRIM27 (Tripartite Motif Containing 27 (TRIM27))

Autre désignation: TRIM27

Sujet:

Synonyms: Zinc finger protein RFP|RING finger protein 76|Ret finger protein|Tripartite motif-containing protein 27|TRIM27|RFP|RNF76

Background: E3 ubiquitin-protein ligase that mediates ubiquitination of PIK3C2B and inhibits its activity, mediates the formation of 'Lys-48'-linked polyubiquitin chains, the function inhibits CD4 T-cell activation. Acts as a regulator of retrograde transport: together with MAGEL2, mediates the formation of 'Lys-63'-linked polyubiquitin chains at 'Lys-220' of WASH1, leading to promote endosomal F-actin assembly(PubMed:23452853). Has a transcriptional repressor activity by cooperating with EPC1. Induces apoptosis by activating Jun N-terminal kinase and p38 kinase and also increases caspase-3-like activity independently of mitochondrial events. May function in male germ cell development. Has DNA-binding activity and preferentially bound to double-stranded DNA.

Poids moléculaire: 58 kDa

ID gène: 5987

UniProt: P14373