RFWD3 anticorps

N° du produit ABIN7118631

Cet anticorps anti-RFWD3 est un anticorps Lapin Polyclonal détectant RFWD3 dans WB, ELISA, IHC et IF. Adapté pour Humain, Souris et Rat.

Aperçu rapide pour RFWD3 anticorps (ABIN7118631)

Antigène: RFWD3 (Ring Finger and WD Repeat Domain 3 (RFWD3))

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp RFWD3 est non-conjugé

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF)

Détail du produit anti-RFWD3 anticorps

Fonction: RFWD3 antibody

Purification: Immunogen affinity purified

Pureté: ≥95 % as determined by SDS-PAGE

Immunogène: ring finger and WD repeat domain 3

Isotype: IgG

Information d'application

Indications d'application: WB: 1:500-1:2000, IHC: 1:20-1:200, IF: 1:20-1:200

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freeze / thaw cycles.

Stock: -20 °C

Stockage commentaire: -20°C for 12 months

Date de péremption: 12 months

Détails sur RFWD3

Antigène: RFWD3 (Ring Finger and WD Repeat Domain 3 (RFWD3))

Autre désignation: RFWD3

Sujet:

Synonyms: E3 ubiquitin-protein ligase RFWD3|RING finger and WD repeat domain-containing protein 3|RING finger protein 201|RFWD3|RNF201

Background: E3 ubiquitin-protein ligase that mediates the ubiquitination of p53/TP53 in the late response to DNA damage, and acts as a positive regulator of p53/TP53 stability, thereby regulating the G1/S DNA damage checkpoint. May act by catalyzing the formation of short polyubiquitin chains on p53/TP53 that are not targeted to the proteasome. In response to ionizing radiation, interacts with MDM2 and enhances p53/TP53 ubiquitination, possibly by restricting MDM2 from extending polyubiquitin chains on ubiquitinated p53/TP53. Plays a role in RPA-mediated DNA damage signaling and repair.

Poids moléculaire: 85 kDa

ID gène: 55159

UniProt: Q6PCD5