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RFWD3 anticorps (C-Term)

RFWD3 Reactivité: Humain WB Hôte: Lapin Polyclonal unconjugated
N° du produit ABIN7466618
  • Antigène Voir toutes RFWD3 Anticorps
    RFWD3 (Ring Finger and WD Repeat Domain 3 (RFWD3))
    Épitope
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    C-Term
    Reactivité
    • 20
    • 1
    • 1
    • 1
    Humain
    Hôte
    • 18
    • 2
    Lapin
    Clonalité
    • 18
    • 2
    Polyclonal
    Conjugué
    • 13
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Cet anticorp RFWD3 est non-conjugé
    Application
    • 11
    • 9
    • 3
    • 3
    • 2
    • 1
    • 1
    Western Blotting (WB)
     Réactivité croisée
    Humain
    Purification
    Purified by antigen-affinity chromatography.
    Immunogène
    Recombinant protein encompassing a sequence within the C-terminus region of human RFWD3. The exact sequence is proprietary.
    Isotype
    IgG
    Top Product
    Discover our top product RFWD3 Anticorps primaire
  • Indications d'application
    WB: 1:500-1:3000. Optimal dilutions/concentrations should be determined by the researcher. Not tested in other applications.
    Commentaires

    Positive Control: MCF-7

    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    0.96 mg/mL
    Buffer
    0.1M Tris-Glycine ( pH 7), 20 % Glycerol, 0.01 % Thimerosal
    Agent conservateur
    Thimerosal (Merthiolate)
    Précaution d'utilisation
    This product contains Thimerosal (Merthiolate): a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Stock
    4 °C,-20 °C
    Stockage commentaire
    Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4°C. For long-term storage, aliquot and store at -20°C or below. Avoid multiple freeze-thaw cycles.
  • Antigène
    RFWD3 (Ring Finger and WD Repeat Domain 3 (RFWD3))
    Autre désignation
    ring finger and WD repeat domain 3 (RFWD3 Produits)
    Synonymes
    anticorps RGD1305243, anticorps RFWD3, anticorps RNF201, anticorps BC027246, anticorps ring finger and WD repeat domain 3, anticorps Rfwd3, anticorps RFWD3
    Sujet
    Ring finger and WD repeat domain 3 , FANCW , RNF201,E3 ubiquitin-protein ligase that mediates the ubiquitination of p53/TP53 in the late response to DNA damage, and acts as a positive regulator of p53/TP53 stability, thereby regulating the G1/S DNA damage checkpoint. May act by catalyzing the formation of short polyubiquitin chains on p53/TP53 that are not targeted to the proteasome. In response to ionizing radiation, interacts with MDM2 and enhances p53/TP53 ubiquitination, possibly by restricting MDM2 from extending polyubiquitin chains on ubiquitinated p53/TP53.
    Poids moléculaire
    85 kDa
    ID gène
    55159
    UniProt
    Q6PCD5
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