RNF41 anticorps

N° du produit ABIN7118659

Cet anticorps Lapin Polyclonal détecte spécifiquement RNF41 dans WB et ELISA. Il présente une réactivité envers Humain, Souris et Rat.

Aperçu rapide pour RNF41 anticorps (ABIN7118659)

Antigène: RNF41 (Ring Finger Protein 41 (RNF41))

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp RNF41 est non-conjugé

Application: Western Blotting (WB), ELISA

Détail du produit anti-RNF41 anticorps

Fonction: RNF41 antibody

Purification: Immunogen affinity purified

Pureté: ≥95 % as determined by SDS-PAGE

Immunogène: ring finger protein 41

Isotype: IgG

Information d'application

Indications d'application: WB: 1:500-1:2000

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freeze / thaw cycles.

Stock: -20 °C

Stockage commentaire: -20°C for 12 months

Date de péremption: 12 months

Détails sur RNF41

Antigène: RNF41 (Ring Finger Protein 41 (RNF41))

Autre désignation: RNF41

Sujet:

Synonyms: E3 ubiquitin-protein ligase NRDP1|RING finger protein 41|RING-type E3 ubiquitin transferase NRDP1|RNF41|FLRF|NRDP1

Background: Acts as E3 ubiquitin-protein ligase and regulates the degradation of target proteins. Polyubiquitinates MYD88. Negatively regulates MYD88-dependent production of proinflammatory cytokines. Can promote TRIF-dependent production of type I interferon and inhibits infection with vesicular stomatitis virus(By similarity). Promotes also activation of TBK1 and IRF3. Involved in the ubiquitination of erythropoietin(EPO) and interleukin-3(IL-3) receptors. Thus, through maintaining basal levels of cytokine receptors, RNF41 is involved in the control of hematopoietic progenitor cell differentiation into myeloerythroid lineages(By similarity). Contributes to the maintenance of steady-state ERBB3 levels by mediating its growth factor-independent degradation. Involved in the degradation of the inhibitor of apoptosis BIRC6 and thus is an important regulator of cell death by promoting apoptosis. Acts also as a PARK2 modifier that accelerates its degradation, resulting in a reduction of PARK2 activity, influencing the balance of intracellular redox state. The RNF41-PARK2 pathway regulates autophagosome-lysosome fusion during late mitophagy. Mitophagy is a selective form of autophagy necessary for mitochondrial quality control(PubMed:24949970).

Poids moléculaire: 36 kDa

ID gène: 10193

UniProt: Q9H4P4

Pathways: SARS-CoV-2 Protein Interactome