RWDD3 anticorps

N° du produit ABIN7118740

Cet anticorps Lapin Polyclonal détecte spécifiquement RWDD3 dans ELISA et IHC. Il présente une réactivité envers Humain.

Aperçu rapide pour RWDD3 anticorps (ABIN7118740)

Antigène: RWDD3 (RWD Domain Containing 3 (RWDD3))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp RWDD3 est non-conjugé

Application: ELISA, Immunohistochemistry (IHC)

Détail du produit anti-RWDD3 anticorps

Fonction: RWDD3 antibody

Purification: Immunogen affinity purified

Pureté: ≥95 % as determined by SDS-PAGE

Immunogène: RWD domain containing 3

Isotype: IgG

Information d'application

Indications d'application: IHC: 1:20-1:200

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freeze / thaw cycles.

Stock: -20 °C

Stockage commentaire: -20°C for 12 months

Date de péremption: 12 months

Détails sur RWDD3

Antigène: RWDD3 (RWD Domain Containing 3 (RWDD3))

Autre désignation: RWDD3

Sujet:

Synonyms: RWD domain-containing protein 3|RWD domain-containing sumoylation enhancer (RSUME)|RWDD3|RSUME

Background: Enhancer of SUMO conjugation. Via its interaction with UBE2I/UBC9, increases SUMO conjugation to proteins by promoting the binding of E1 and E2 enzymes, thioester linkage between SUMO and UBE2I/UBC9 and transfer of SUMO to specific target proteins which include HIF1A, PIAS, NFKBIA, NR3C1 and TOP1. Isoform 1 and isoform 2 positively regulate the NF-kappa-B signaling pathway by enhancing the sumoylation of NF-kappa-B inhibitor alpha(NFKBIA), promoting its stabilization which consequently leads to an increased inhibition of NF-kappa-B transcriptional activity. Isoform 1 and isoform 2 negatively regulate the hypoxia-inducible factor-1 alpha(HIF1A) signaling pathway by increasing the sumoylation of HIF1A, promoting its stabilization, transcriptional activity and the expression of its target gene VEGFA during hypoxia. Isoform 2 promotes the sumoylation and transcriptional activity of the glucocorticoid receptor NR3C1 and enhances the interaction of SUMO1 and NR3C1 with UBE2I/UBC9. Has no effect on ubiquitination.

ID gène: 25950

UniProt: Q9Y3V2