SIRT5 anticorps

N° du produit ABIN7119113

L’anticorps Lapin Polyclonal anti-SIRT5 a été validé pour WB, ELISA et IP. Il convient pour détecter SIRT5 dans des échantillons de Humain, Souris et Rat.

Aperçu rapide pour SIRT5 anticorps (ABIN7119113)

Antigène: SIRT5 (Sirtuin 5 (SIRT5))

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp SIRT5 est non-conjugé

Application: Western Blotting (WB), ELISA, Immunoprecipitation (IP)

Détail du produit anti-SIRT5 anticorps

Fonction: SIRT5 antibody

Purification: Immunogen affinity purified

Pureté: ≥95 % as determined by SDS-PAGE

Immunogène: sirtuin(silent mating type information regulation 2 homolog) 5

Isotype: IgG

Information d'application

Indications d'application: WB: 1:500-1:1000, IP: 1:500-1:1000, IF: 1:50-1:500

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freeze / thaw cycles.

Stock: -20 °C

Stockage commentaire: -20°C for 12 months

Date de péremption: 12 months

Détails sur SIRT5

Antigène: SIRT5 (Sirtuin 5 (SIRT5))

Autre désignation: SIRT5

Sujet:

Synonyms: NAD-dependent protein deacylase sirtuin-5, mitochondrial|Regulatory protein SIR2 homolog 5|SIR2-like protein 5|SIRT5|SIR2L5

Background: NAD-dependent lysine demalonylase, desuccinylase and deglutarylase that specifically removes malonyl, succinyl and glutaryl groups on target proteins(PubMed:21908771, PubMed:22076378, PubMed:24703693). Activates CPS1 and contributes to the regulation of blood ammonia levels during prolonged fasting: acts by mediating desuccinylation and deglutarylation of CPS1, thereby increasing CPS1 activity in response to elevated NAD levels during fasting(PubMed:22076378, PubMed:24703693). Activates SOD1 by mediating its desuccinylation, leading to reduced reactive oxygen species(PubMed:24140062). Modulates ketogenesis through the desuccinylation and activation of HMGCS2(By similarity). Has weak NAD-dependent protein deacetylase activity, however this activity may not be physiologically relevant in vivo. Can deacetylate cytochrome c(CYCS) and a number of other proteins in vitro such as UOX.

Poids moléculaire: 33 kDa

UniProt: Q9NXA8

Pathways: SARS-CoV-2 Protein Interactome