SIRT6 anticorps (AA 1-192)

N° du produit ABIN7119114

Cet anticorps anti-SIRT6 est un anticorps Lapin Polyclonal détectant SIRT6 dans WB, IHC et ELISA. Adapté pour Humain, Souris et Rat.

Aperçu rapide pour SIRT6 anticorps (AA 1-192) (ABIN7119114)

Antigène: SIRT6 (Sirtuin 6 (SIRT6))

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp SIRT6 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC), ELISA

Détail du produit anti-SIRT6 anticorps

Épitope: AA 1-192

Fonction: SIRT6 antibody

Purification: Immunogen affinity purified

Pureté: ≥95 % as determined by SDS-PAGE

Immunogène:

Immunogen sequence: 1-192aa

Immunogen: sirtuin(silent mating type information regulation 2 homolog) 6

Isotype: IgG

Information d'application

Indications d'application: WB: 1:200-1:2000, IHC: 1:50-1:200

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freeze / thaw cycles.

Stock: -20 °C

Stockage commentaire: -20°C for 12 months

Date de péremption: 12 months

Détails sur SIRT6

Antigène: SIRT6 (Sirtuin 6 (SIRT6))

Autre désignation: SIRT6

Sujet:

Synonyms: NAD-dependent protein deacylase sirtuin-6|NAD-dependent protein deacetylase sirtuin-6|Protein mono-ADP-ribosyltransferase sirtuin-6|Regulatory protein SIR2 homolog 6 (hSIRT6)|SIR2-like protein 6|SIRT6|SIR2L6

Background: NAD-dependent protein deacetylase. Has deacetylase activity towards histone H3K9Ac and H3K56Ac. Modulates acetylation of histone H3 in telomeric chromatin during the S-phase of the cell cycle. Deacetylates histone H3K9Ac at NF-kappa-B target promoters and may down-regulate the expression of a subset of NF-kappa-B target genes. Acts as a corepressor of the transcription factor HIF1A to control the expression of multiple glycolytic genes to regulate glucose homeostasis. Required for genomic stability. Regulates the production of TNF protein. Has a role in the regulation of life span(By similarity). Deacetylation of nucleosomes interferes with RELA binding to target DNA. May be required for the association of WRN with telomeres during S-phase and for normal telomere maintenance. Required for genomic stability. Required for normal IGF1 serum levels and normal glucose homeostasis. Modulates cellular senescence and apoptosis. On DNA damage, promotes DNA end resection via deacetylation of RBBP8. Has very weak deacetylase activity and can bind NAD(+) in the absence of acetylated substrate.

Poids moléculaire: 49 kDa

ID gène: 23408

UniProt: Q8N6T7