SIX Homeobox 1 anticorps

N° du produit ABIN7119116

L’anticorps Lapin Polyclonal anti-SIX Homeobox 1 a été validé pour WB, ELISA, IF et IP. Il convient pour détecter SIX Homeobox 1 dans des échantillons de Humain et Souris.

Aperçu rapide pour SIX Homeobox 1 anticorps (ABIN7119116)

Antigène: SIX Homeobox 1 (SIX1)

Reactivité: Humain, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp SIX Homeobox 1 est non-conjugé

Application: Western Blotting (WB), ELISA, Immunofluorescence (IF), Immunoprecipitation (IP)

Détail du produit anti-SIX Homeobox 1 anticorps

Fonction: SIX1 antibody

Purification: Immunogen affinity purified

Pureté: ≥95 % as determined by SDS-PAGE

Immunogène: SIX homeobox 1

Isotype: IgG

Information d'application

Indications d'application: WB: 1:500-1:2000, IP: 1:200-1:1000, IF: 1:20-1:200

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freeze / thaw cycles.

Stock: -20 °C

Stockage commentaire: -20°C for 12 months

Date de péremption: 12 months

Détails sur SIX Homeobox 1

Antigène: SIX Homeobox 1 (SIX1)

Autre désignation: SIX1

Sujet:

Synonyms: Homeobox protein SIX1|Sine oculis homeobox homolog 1|SIX1

Background: Transcription factor that is involved in the regulation of cell proliferation, apoptosis and embryonic development. Plays an important role in the development of several organs, including kidney, muscle and inner ear. Depending on context, functions as transcriptional repressor or activator. Lacks an activation domain, and requires interaction with EYA family members for transcription activation. Mediates nuclear translocation of EYA1 and EYA2. Binds the 5'-TCA[AG][AG]TTNC-3' motif present in the MEF3 element in the MYOG promoter. Regulates the expression of numerous genes, including MYC, CCND1 and EZR. Acts as activator of the IGFBP5 promoter, probably coactivated by EYA2. Repression of precursor cell proliferation in myoblasts is switched to activation through recruitment of EYA3 to the SIX1-DACH1 complex. During myogenesis, seems to act together with EYA2 and DACH2(By similarity). Regulates the expression of CCNA1.

Poids moléculaire: 32-35 kDa

ID gène: 6495

UniProt: Q15475

Pathways: Sensory Perception of Sound, Regulation of Muscle Cell Differentiation, Tube Formation, Skeletal Muscle Fiber Development