Sphingomyelin Synthase 1 anticorps

N° du produit ABIN7119418

Cet anticorps Lapin Polyclonal détecte spécifiquement Sphingomyelin Synthase 1 dans WB, ELISA et IHC. Il présente une réactivité envers Humain, Souris et Rat.

Aperçu rapide pour Sphingomyelin Synthase 1 anticorps (ABIN7119418)

Antigène: Sphingomyelin Synthase 1 (SGMS1)

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp Sphingomyelin Synthase 1 est non-conjugé

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC)

Détail du produit anti-Sphingomyelin Synthase 1 anticorps

Fonction: SGMS1 antibody

Purification: Immunogen affinity purified

Pureté: ≥95 % as determined by SDS-PAGE

Immunogène: sphingomyelin synthase 1

Isotype: IgG

Information d'application

Indications d'application: WB: 1:500-1:2000, IHC: 1:20-1:200

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freeze / thaw cycles.

Stock: -20 °C

Stockage commentaire: -20°C for 12 months

Date de péremption: 12 months

Détails sur Sphingomyelin Synthase 1

Antigène: Sphingomyelin Synthase 1 (SGMS1)

Autre désignation: SGMS1

Sujet:

Synonyms: Phosphatidylcholine:ceramide cholinephosphotransferase 1|Medulla oblongata-derived protein (Protein Mob)|Sphingomyelin synthase 1|Transmembrane protein 23|SGMS1|MOB|SMS1|TMEM23

Background: Sphingomyelin synthases synthesize the sphingolipid, sphingomyelin, through transfer of the phosphatidyl head group, phosphatidylcholine, on to the primary hydroxyl of ceramide. The reaction is bidirectional depending on the respective levels of the sphingolipid and ceramide. Golgi apparatus SMS1 directly and specifically recognizes the choline head group on the substrate, requiring two fatty chains on the choline-P donor molecule in order to be recognized efficiently as a substrate. Major form in macrophages. Required for cell growth in certain cell types such as HeLa cells. Suppresses BAX-mediated apoptosis and also prevents cell death in response to stimuli such as hydrogen peroxide, osmotic stress, elevated temperature and exogenously supplied sphingolipids. May protect against cell death by reversing the stress-inducible increase in levels of proapoptotic ceramide.

Poids moléculaire: 50 kDa

ID gène: 259230

UniProt: Q86VZ5

Pathways: Cellular Response to Molecule of Bacterial Origin