SFPQ anticorps

N° du produit ABIN7119440

L’anticorps Lapin Polyclonal anti-SFPQ a été validé pour WB, IHC et ELISA. Il convient pour détecter SFPQ dans des échantillons de Humain, Souris et Rat.

Aperçu rapide pour SFPQ anticorps (ABIN7119440)

Antigène: SFPQ (Splicing Factor Proline/glutamine-Ric (SFPQ))

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp SFPQ est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC), ELISA

Détail du produit anti-SFPQ anticorps

Fonction: SFPQ antibody

Purification: Immunogen affinity purified

Pureté: ≥95 % as determined by SDS-PAGE

Immunogène: splicing factor proline/glutamine-rich (polypyrimidine tract binding protein associated)

Isotype: IgG

Information d'application

Indications d'application: WB: 1:500 - 1:1000, IHC: 1:50 - 1:200

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freeze / thaw cycles.

Stock: -20 °C

Stockage commentaire: -20°C for 12 months

Date de péremption: 12 months

Détails sur SFPQ

Antigène: SFPQ (Splicing Factor Proline/glutamine-Ric (SFPQ))

Autre désignation: SFPQ

Sujet:

Synonyms: Splicing factor, proline- and glutamine-rich|100 kDa DNA-pairing protein (hPOMp100)|DNA-binding p52/p100 complex, 100 kDa subunit|Polypyrimidine tract-binding protein-associated-splicing factor (PSF, PTB-associated-splicing factor)|SFPQ|PSF

Background: SFPQ, also named PSF, encodes a nuclear factor implicated in the splicing and regulation of gene expression. SFPQ probably forms a heteromer with NONO and participates in DNA pairing and DNA break repair program. Very recently SFPQ was identified as a downstream target of tau, complete nuclear depletion and cytoplasmic accumulation of SFPQ were shown in the neurons and astrocytes of brains with Alzheimer's disease (AD), more strikingly, reduced SFPQ levels may progress together with tau pathology, these observation strongly suggests the important role of SFPQ pathology in neurodegenerative diseases including AD. SFPQ protein may appears as 47 kDa, 52 kDa or 100 kDa molecules in various cell types. This antibody is a rabbit polyclonal antibody raised against the N-terminal of human SFPQ.

Poids moléculaire: 115 kDa

ID gène: 6421

UniProt: P23246