TEAD4 anticorps

N° du produit ABIN7119813

Cet anticorps anti-TEAD4 est un anticorps Lapin Polyclonal détectant TEAD4 dans WB, ELISA et IP. Adapté pour Humain, Souris et Rat.

Aperçu rapide pour TEAD4 anticorps (ABIN7119813)

Antigène: TEAD4 (TEA Domain Family Member 4 (TEAD4))

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp TEAD4 est non-conjugé

Application: Western Blotting (WB), ELISA, Immunoprecipitation (IP)

Détail du produit anti-TEAD4 anticorps

Fonction: TEAD4 antibody

Purification: Immunogen affinity purified

Pureté: ≥95 % as determined by SDS-PAGE

Immunogène: TEA domain family member 4

Isotype: IgG

Information d'application

Indications d'application: WB: 1:500-1:2000, IP: 1:200-1:1000

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freeze / thaw cycles.

Stock: -20 °C

Stockage commentaire: -20°C for 12 months

Date de péremption: 12 months

Détails sur TEAD4

Antigène: TEAD4 (TEA Domain Family Member 4 (TEAD4))

Autre désignation: TEAD4

Sujet:

Synonyms: Transcriptional enhancer factor TEF-3|TEA domain family member 4 (TEAD-4)|Transcription factor 13-like 1|Transcription factor RTEF-1|TEAD4|RTEF1|TCF13L1|TEF3

Background: Transcription factor which plays a key role in the Hippo signaling pathway, a pathway involved in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein MST1/MST2, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Acts by mediating gene expression of YAP1 and WWTR1/TAZ, thereby regulating cell proliferation, migration and epithelial mesenchymal transition(EMT) induction. Binds specifically and non-cooperatively to the Sph and GT-IIC 'enhansons'(5'-GTGGAATGT-3') and activates transcription. Binds to the M-CAT motif.

Poids moléculaire: 50-55 kDa

ID gène: 7004

UniProt: Q15561

Pathways: Regulation of Lipid Metabolism by PPARalpha