TPX2 anticorps (AA 1-256)

N° du produit ABIN7120029

Cet anticorps anti-TPX2 est un anticorps Lapin Polyclonal détectant TPX2 dans WB, ELISA, IP et IF. Adapté pour Humain, Souris et Rat.

Aperçu rapide pour TPX2 anticorps (AA 1-256) (ABIN7120029)

Antigène: TPX2 (TPX2, Microtubule-Associated, Homolog (Xenopus Laevis) (TPX2))

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp TPX2 est non-conjugé

Application: Western Blotting (WB), ELISA, Immunoprecipitation (IP), Immunofluorescence (IF)

Détail du produit anti-TPX2 anticorps

Épitope: AA 1-256

Fonction: TPX2 antibody

Purification: Immunogen affinity purified

Pureté: ≥95 % as determined by SDS-PAGE

Immunogène:

Immunogen sequence: 1-256aa

Immunogen: TPX2, microtubule-associated, homolog(Xenopus laevis)

Isotype: IgG

Information d'application

Indications d'application: WB: 1:500-1:2000, IP: 1:200-1:1000, IF: 1:20-1:200

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freeze / thaw cycles.

Stock: -20 °C

Stockage commentaire: -20°C for 12 months

Date de péremption: 12 months

Détails sur TPX2

Antigène: TPX2 (TPX2, Microtubule-Associated, Homolog (Xenopus Laevis) (TPX2))

Autre désignation: TPX2

Sujet:

Synonyms: Targeting protein for Xklp2|Differentially expressed in cancerous and non-cancerous lung cells 2 (DIL-2)|Hepatocellular carcinoma-associated antigen 519|Hepatocellular carcinoma-associated antigen 90|Protein fls353|Restricted expression proliferation-associated protein 100 (p100)|TPX2|C20orf1|C20orf2|DIL2|HCA519

Background: Spindle assembly factor required for normal assembly of mitotic spindles. Required for normal assembly of microtubules during apoptosis. Required for chromatin and/or kinetochore dependent microtubule nucleation. Mediates AURKA localization to spindle microtubules(PubMed:18663142, PubMed:19208764). Activates AURKA by promoting its autophosphorylation at 'Thr-288' and protects this residue against dephosphorylation(PubMed:18663142, PubMed:19208764). TPX2 is inactivated upon binding to importin-alpha(PubMed:26165940). At the onset of mitosis, GOLGA2 interacts with importin-alpha, liberating TPX2 from importin-alpha, allowing TPX2 to activates AURKA kinase and stimulates local microtubule nucleation(PubMed:26165940).

Poids moléculaire: 100 kDa

ID gène: 22974

UniProt: Q9ULW0