TRIM11 anticorps

N° du produit ABIN7120272

Détail du produit anti-TRIM11 anticorps

Antigène: TRIM11 (Tripartite Motif Containing 11 (TRIM11))

Reactivité: Humain, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp TRIM11 est non-conjugé

Application: ELISA, Western Blotting (WB), Immunohistochemistry (IHC)

Purification: Immunogen affinity purified

Pureté: ≥95 % as determined by SDS-PAGE

Immunogène: tripartite motif-containing 11

Isotype: IgG

Information d'application

Indications d'application: WB: 1:200-1:1000, IHC: 1:20-1:200

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: -20°C for 12 months (Avoid repeated freeze / thaw cycles.)

Date de péremption: 12 months

Détails sur TRIM11

Antigène: TRIM11 (Tripartite Motif Containing 11 (TRIM11))

Autre désignation: TRIM11 (TRIM11 Produits)

Synonymes: anticorps BIA1, anticorps RNF92, anticorps TRIM11, anticorps tripartite motif containing 11, anticorps tripartite motif-containing 11, anticorps TRIM11, anticorps Trim11

Sujet: Synonyms:BIA1, Protein BIA1, RING finger protein 92, RNF92, TRIM11, tripartite motif containing 11 Background:E3 ubiquitin-protein ligase that promotes the degradation of insoluble ubiquitinated proteins, including insoluble PAX6, poly-Gln repeat expanded HTT and poly-Ala repeat expanded ARX. Mediates PAX6 ubiquitination leading to proteasomal degradation, thereby modulating cortical neurogenesis. May also inhibit PAX6 transcriptional activity, possibly in part by preventing the binding of PAX6 to its consensus sequences. May contribute to the regulation of the intracellular level of HN(humanin) or HN-containing proteins through the proteasomal degradation pathway. Mediates MED15 ubiquitination leading to proteasomal degradation. May contribute to the innate restriction of retroviruses. Upon overexpression, reduces HIV-1 and murine leukemia virus infectivity, by suppressing viral gene expression. Antiviral activity depends on a functional E3 ubiquitin-protein ligase domain. May regulate TRIM5 turnover via the proteasome pathway, thus counteracting the TRIM5-mediated cross-species restriction of retroviral infection at early stages of the retroviral life cycle.

Poids moléculaire: 52 kDa

ID gène: 81559

UniProt: Q96F44