TRIM24 anticorps

N° du produit ABIN7120279

Cet anticorps Lapin Polyclonal détecte spécifiquement TRIM24 dans WB, ELISA, IHC et IP. Il présente une réactivité envers Humain, Souris et Rat.

Aperçu rapide pour TRIM24 anticorps (ABIN7120279)

Antigène: TRIM24 (Tripartite Motif Containing 24 (TRIM24))

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp TRIM24 est non-conjugé

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunoprecipitation (IP)

Détail du produit anti-TRIM24 anticorps

Fonction: TRIM24 antibody

Purification: Immunogen affinity purified

Pureté: ≥95 % as determined by SDS-PAGE

Immunogène: tripartite motif-containing 24

Isotype: IgG

Information d'application

Indications d'application: WB: 1:500-1:5000, IP: 1:200-1:2000, IHC: 1:50-1:200, IF: 1:50-1:500

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freeze / thaw cycles.

Stock: -20 °C

Stockage commentaire: -20°C for 12 months

Date de péremption: 12 months

Détails sur TRIM24

Antigène: TRIM24 (Tripartite Motif Containing 24 (TRIM24))

Autre désignation: TRIM24

Sujet:

Synonyms: Transcription intermediary factor 1-alpha (TIF1-alpha)|E3 ubiquitin-protein ligase TRIM24|RING finger protein 82|RING-type E3 ubiquitin transferase TIF1-alpha|Tripartite motif-containing protein 24|TRIM24|RNF82|TIF1|TIF1A

Background: Transcriptional coactivator that interacts with numerous nuclear receptors and coactivators and modulates the transcription of target genes. Interacts with chromatin depending on histone H3 modifications, having the highest affinity for histone H3 that is both unmodified at 'Lys-4'(H3K4me0) and acetylated at 'Lys-23'(H3K23ac). Has E3 protein-ubiquitin ligase activity. Promotes ubiquitination and proteasomal degradation of p53/TP53. Plays a role in the regulation of cell proliferation and apoptosis, at least in part via its effects on p53/TP53 levels. Up-regulates ligand-dependent transcription activation by AR, GCR/NR3C1, thyroid hormone receptor(TR) and ESR1. Modulates transcription activation by retinoic acid(RA) receptors, including RARA. Plays a role in regulating retinoic acid-dependent proliferation of hepatocytes(By similarity).

Poids moléculaire: 117 kDa

ID gène: 8805

UniProt: O15164