TWEAK anticorps

N° du produit ABIN7120388

L’anticorps Lapin Polyclonal anti-TWEAK a été validé pour WB, ELISA et IHC. Il convient pour détecter TWEAK dans des échantillons de Humain, Souris et Rat.

Aperçu rapide pour TWEAK anticorps (ABIN7120388)

Antigène: TWEAK (TNFSF12) (Tumor Necrosis Factor (Ligand) Superfamily, Member 12 (TNFSF12))

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp TWEAK est non-conjugé

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC)

Détail du produit anti-TWEAK anticorps

Fonction: TNFSF12 antibody

Purification: Immunogen affinity purified

Pureté: ≥95 % as determined by SDS-PAGE

Immunogène: tumor necrosis factor (ligand) superfamily, member 12

Isotype: IgG

Information d'application

Indications d'application: WB: 1:500 - 1:2000, IHC: 1:50 - 1:200

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freeze / thaw cycles.

Stock: -20 °C

Stockage commentaire: -20°C for 12 months

Date de péremption: 12 months

Détails sur TWEAK

Antigène: TWEAK (TNFSF12) (Tumor Necrosis Factor (Ligand) Superfamily, Member 12 (TNFSF12))

Autre désignation: TNFSF12

Sujet:

Synonyms: Tumor necrosis factor ligand superfamily member 12|APO3 ligand|TNF-related weak inducer of apoptosis (TWEAK)|Tumor necrosis factor ligand superfamily member 12, membrane form|Tumor necrosis factor ligand superfamily member 12, secreted form|TNFSF12|APO3L|DR3LG

Background: The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This protein is a ligand for the FN14/TWEAKR receptor. This cytokine has overlapping signaling functions with TNF, but displays a much wider tissue distribution. This cytokine, which exists in both membrane-bound and secreted forms, can induce apoptosis via multiple pathways of cell death in a cell type-specific manner. This cytokine is also found to promote proliferation and migration of endothelial cells, and thus acts as a regulator of angiogenesis. Alternative splicing results in multiple transcript variants. Some transcripts skip the last exon of this gene and continue into the second exon of the neighboring TNFSF13 gene, such read-through transcripts are contained in GeneID 407977, TNFSF12-TNFSF13.

Poids moléculaire: 25 kDa

ID gène: 8742

UniProt: O43508

Pathways: Apoptose