Ubiquilin 1 anticorps

N° du produit ABIN7120456

Cet anticorps Lapin Polyclonal détecte spécifiquement Ubiquilin 1 dans WB, ELISA, IHC et IF. Il présente une réactivité envers Humain et Rat.

Aperçu rapide pour Ubiquilin 1 anticorps (ABIN7120456)

Antigène: Ubiquilin 1 (UBQLN1)

Reactivité: Humain, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp Ubiquilin 1 est non-conjugé

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF)

Détail du produit anti-Ubiquilin 1 anticorps

Fonction: UBQLN1 antibody

Purification: Immunogen affinity purified

Pureté: ≥95 % as determined by SDS-PAGE

Immunogène: ubiquilin 1

Isotype: IgG

Information d'application

Indications d'application: WB: 1:200-1:1000, IF: 1:10-1:100, IHC: 1:20-1:200

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freeze / thaw cycles.

Stock: -20 °C

Stockage commentaire: -20°C for 12 months

Date de péremption: 12 months

Détails sur Ubiquilin 1

Antigène: Ubiquilin 1 (UBQLN1)

Autre désignation: UBQLN1

Sujet:

Synonyms: Ubiquilin-1|Protein linking IAP with cytoskeleton 1 (PLIC-1, hPLIC-1)|UBQLN1|DA41|PLIC1

Background: UBQLN1, also known as DSK2 or Ubiquilin 1, is an ubiquitin-like proteinis contains a?N-terminal?ubiquitin-like?domain?and a C-terminal ubiquitin-associated domain.?They physically associate with both proteasomes and ubiquitin ligases, and thus are thought to functionally link the ubiquitination machinery to the proteasome to affect in vivo protein degradation.Ubiquilin has also been shown to modulate accumulation of presenilin proteins, and is found in lesions associated with?Alzheimer's?and?Parkinson's?disease. Two transcript variants encoding different isoforms have been found for this gene. Higher levels of ubiquilin-1 in the brain decreased malformation of the APP molecule which plays a key role in triggering Alzheimers disease.Conversely, lower levels of ubiquilin-1 in the brain were associated with increased malformation of APP?(PMID: 21852239). This antibody detects 70kD band of UBQLN1.

Poids moléculaire: 71 kDa

UniProt: Q9UMX0