GALE anticorps

N° du produit ABIN7120594

Cet anticorps Lapin Polyclonal détecte spécifiquement GALE dans WB, ELISA, IHC et IF. Il présente une réactivité envers Humain, Souris et Rat.

Aperçu rapide pour GALE anticorps (ABIN7120594)

Antigène: GALE (UDP-Galactose-4-Epimerase (GALE))

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp GALE est non-conjugé

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF)

Détail du produit anti-GALE anticorps

Fonction: GALE antibody

Purification: Immunogen affinity purified

Pureté: ≥95 % as determined by SDS-PAGE

Immunogène: UDP-galactose-4-epimerase

Isotype: IgG

Information d'application

Indications d'application: WB: 1:500 - 1:2000, IHC: 1:50 - 1:200, IF: 1:10 - 1:100

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freeze / thaw cycles.

Stock: -20 °C

Stockage commentaire: -20°C for 12 months

Date de péremption: 12 months

Détails sur GALE

Antigène: GALE (UDP-Galactose-4-Epimerase (GALE))

Autre désignation: GALE

Sujet:

Synonyms: UDP-glucose 4-epimerase|Galactowaldenase|UDP-N-acetylgalactosamine 4-epimerase (UDP-GalNAc 4-epimerase)|UDP-N-acetylglucosamine 4-epimerase (UDP-GlcNAc 4-epimerase)|UDP-galactose 4-epimerase|GALE

Background: This gene encodes UDP-galactose-4-epimerase which catalyzes two distinct but analogous reactions: the epimerization of UDP-glucose to UDP-galactose, and the epimerization of UDP-N-acetylglucosamine to UDP-N-acetylgalactosamine. The bifunctional nature of the enzyme has the important metabolic consequence that mutant cells (or individuals) are dependent not only on exogenous galactose, but also on exogenous N-acetylgalactosamine as a necessary precursor for the synthesis of glycoproteins and glycolipids. Mutations in this gene result in epimerase-deficiency galactosemia, also referred to as galactosemia type 3, a disease characterized by liver damage, early-onset cataracts, deafness and mental retardation, with symptoms ranging from mild ('peripheral' form) to severe ('generalized' form). Multiple alternatively spliced transcripts encoding the same protein have been identified.

Poids moléculaire: 36 kDa

ID gène: 2582

UniProt: Q14376

Pathways: Response to Water Deprivation, Cellular Glucan Metabolic Process