UPF3A anticorps

N° du produit ABIN7120628

L’anticorps anti-UPF3A Polyclonal Lapin est utilisé pour la détection de UPF3A dans des échantillons de Humain, Souris et Rat. Il a été validé pour WB, ELISA et IHC.

Aperçu rapide pour UPF3A anticorps (ABIN7120628)

Antigène: UPF3A (UPF3 Regulator of Nonsense Transcripts Homolog A (UPF3A))

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp UPF3A est non-conjugé

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC)

Détail du produit anti-UPF3A anticorps

Fonction: UPF3A antibody

Purification: Immunogen affinity purified

Pureté: ≥95 % as determined by SDS-PAGE

Immunogène: UPF3 regulator of nonsense transcripts homolog A(yeast)

Isotype: IgG

Information d'application

Indications d'application: WB: 1:500-1:5000, IHC:1:20-1:200,IF: 1:20-1:200

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freeze / thaw cycles.

Stock: -20 °C

Stockage commentaire: -20°C for 12 months

Date de péremption: 12 months

Détails sur UPF3A

Antigène: UPF3A (UPF3 Regulator of Nonsense Transcripts Homolog A (UPF3A))

Autre désignation: UPF3A

Sujet:

Synonyms: Regulator of nonsense transcripts 3A|Nonsense mRNA reducing factor 3A|Up-frameshift suppressor 3 homolog A (hUpf3)|UPF3A|RENT3A|UPF3

Background: Involved in nonsense-mediated decay(NMD) of mRNAs containing premature stop codons by associating with the nuclear exon junction complex(EJC) and serving as link between the EJC core and NMD machinery. Recruits UPF2 at the cytoplasmic side of the nuclear envelope and the subsequent formation of an UPF1-UPF2-UPF3 surveillance complex(including UPF1 bound to release factors at the stalled ribosome) is believed to activate NMD. However, UPF3A is shown to be only marginally active in NMD as compared to UPF3B. Binds spliced mRNA upstream of exon-exon junctions. In vitro, weakly stimulates translation.

Poids moléculaire: 51 kDa

ID gène: 65110

UniProt: Q9H1J1