VPS11 anticorps

N° du produit ABIN7120703

L’anticorps Lapin Polyclonal anti-VPS11 a été validé pour WB, ELISA, IP, IF et FACS. Il convient pour détecter VPS11 dans des échantillons de Humain, Souris et Rat.

Aperçu rapide pour VPS11 anticorps (ABIN7120703)

Antigène: VPS11 (Vacuolar Protein Sorting 11 Homolog (VPS11))

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp VPS11 est non-conjugé

Application: Western Blotting (WB), ELISA, Immunoprecipitation (IP), Immunofluorescence (IF), Flow Cytometry (FACS)

Détail du produit anti-VPS11 anticorps

Fonction: VPS11 antibody

Purification: Immunogen affinity purified

Pureté: ≥95 % as determined by SDS-PAGE

Immunogène: vacuolar protein sorting 11 homolog

Isotype: IgG

Information d'application

Indications d'application: WB: 1:500-1:5000, IF: 1:10-1:100, IP: 1:200-1:2000, FC:N/A

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freeze / thaw cycles.

Stock: -20 °C

Stockage commentaire: -20°C for 12 months

Date de péremption: 12 months

Détails sur VPS11

Antigène: VPS11 (Vacuolar Protein Sorting 11 Homolog (VPS11))

Autre désignation: VPS11

Sujet:

Synonyms: Vacuolar protein sorting-associated protein 11 homolog (hVPS11)|RING finger protein 108|VPS11|RNF108

Background: Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport and autophagic pathways. Believed to act as a core component of the putative HOPS and CORVET endosomal tethering complexes which are proposed to be involved in the Rab5-to-Rab7 endosome conversion probably implicating MON1A/B, and via binding SNAREs and SNARE complexes to mediate tethering and docking events during SNARE-mediated membrane fusion. The HOPS complex is proposed to be recruited to Rab7 on the late endosomal membrane and to regulate late endocytic, phagocytic and autophagic traffic towards lysosomes. The CORVET complex is proposed to function as a Rab5 effector to mediate early endosome fusion probably in specific endosome subpopulations(PubMed:11382755, PubMed:23351085, PubMed:24554770, PubMed:25266290, PubMed:25783203). Required for fusion of endosomes and autophagosomes with lysosomes(PubMed:25783203). Involved in cargo transport from early to late endosomes and required for the transition from early to late endosomes(PubMed:21148287). Involved in the retrograde Shiga toxin transport(PubMed:23593995).

Poids moléculaire: 108 kDa

ID gène: 55823

UniProt: Q9H270

Pathways: SARS-CoV-2 Protein Interactome