VPS18 anticorps

N° du produit ABIN7120704

Cet anticorps anti-VPS18 est un anticorps Lapin Polyclonal détectant VPS18 dans ELISA, IP, IHC, FACS et IF. Adapté pour Humain, Souris et Rat.

Aperçu rapide pour VPS18 anticorps (ABIN7120704)

Antigène: VPS18 (Vacuolar Protein Sorting 18 Homolog (VPS18))

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp VPS18 est non-conjugé

Application: ELISA, Immunoprecipitation (IP), Immunohistochemistry (IHC), Flow Cytometry (FACS), Immunofluorescence (IF)

Détail du produit anti-VPS18 anticorps

Fonction: VPS18 antibody

Purification: Immunogen affinity purified

Pureté: ≥95 % as determined by SDS-PAGE

Immunogène: vacuolar protein sorting 18 homolog

Isotype: IgG

Information d'application

Indications d'application: WB: 1:200-1:1000, IHC: 1:50-1:500, IP: 1:200-1:1000, IF: 1:20-1:200

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freeze / thaw cycles.

Stock: -20 °C

Stockage commentaire: -20°C for 12 months

Date de péremption: 12 months

Détails sur VPS18

Antigène: VPS18 (Vacuolar Protein Sorting 18 Homolog (VPS18))

Autre désignation: VPS18

Sujet:

Synonyms: Vacuolar protein sorting-associated protein 18 homolog (hVPS18)|VPS18|KIAA1475

Background: Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport and autophagic pathways. Believed to act as a core component of the putative HOPS and CORVET endosomal tethering complexes which are proposed to be involved in the Rab5-to-Rab7 endosome conversion probably implicating MON1A/B, and via binding SNAREs and SNARE complexes to mediate tethering and docking events during SNARE-mediated membrane fusion. The HOPS complex is proposed to be recruited to Rab7 on the late endosomal membrane and to regulate late endocytic, phagocytic and autophagic traffic towards lysosomes. The CORVET complex is proposed to function as a Rab5 effector to mediate early endosome fusion probably in specific endosome subpopulations(PubMed:11382755, PubMed:23351085, PubMed:24554770, PubMed:25783203). Required for fusion of endosomes and autophagosomes with lysosomes(PubMed:25783203). Involved in dendrite development of Pukinje cells(By similarity).

Poids moléculaire: 110 kDa

ID gène: 57617

UniProt: Q9P253

Pathways: Asymmetric Protein Localization