VPS33A anticorps

N° du produit ABIN7120707

Cet anticorps anti-VPS33A est un anticorps Lapin Polyclonal détectant VPS33A dans ELISA et WB. Adapté pour Humain, Souris et Rat.

Aperçu rapide pour VPS33A anticorps (ABIN7120707)

Antigène: VPS33A (Vacuolar Protein Sorting 33 Homolog A (VPS33A))

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp VPS33A est non-conjugé

Application: ELISA, Western Blotting (WB)

Détail du produit anti-VPS33A anticorps

Fonction: VPS33A antibody

Purification: Immunogen affinity purified

Pureté: ≥95 % as determined by SDS-PAGE

Immunogène: vacuolar protein sorting 33 homolog A

Isotype: IgG

Information d'application

Indications d'application: WB: 1:500-1:5000, IP: 1:200-1:2000

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freeze / thaw cycles.

Stock: -20 °C

Stockage commentaire: -20°C for 12 months

Date de péremption: 12 months

Détails sur VPS33A

Antigène: VPS33A (Vacuolar Protein Sorting 33 Homolog A (VPS33A))

Autre désignation: VPS33A

Sujet:

Synonyms: Vacuolar protein sorting-associated protein 33A (hVPS33A)|VPS33A

Background: Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport and autophagic pathways. Believed to act as a core component of the putative HOPS and CORVET endosomal tethering complexes which are proposed to be involved in the Rab5-to-Rab7 endosome conversion probably implicating MON1A/B, and via binding SNAREs and SNARE complexes to mediate tethering and docking events during SNARE-mediated membrane fusion. The HOPS complex is proposed to be recruited to Rab7 on the late endosomal membrane and to regulate late endocytic, phagocytic and autophagic traffic towards lysosomes. The CORVET complex is proposed to function as a Rab5 effector to mediate early endosome fusion probably in specific endosome subpopulations(PubMed:23351085, PubMed:24554770, PubMed:25266290, PubMed:25783203). Required for fusion of endosomes and autophagosomes with lysosomes, the function is dependent on its association with VPS16 but not VIPAS39(PubMed:25783203). The function in autophagosome-lysosome fusion implicates STX17 but not UVRAG(PubMed:24554770).

Poids moléculaire: 68 kDa

ID gène: 65082

UniProt: Q96AX1