VPS33A anticorps (AA 1-300) (HRP)

N° du produit ABIN7175311

Détail du produit anti-VPS33A anticorps (HRP)

Antigène: VPS33A (Vacuolar Protein Sorting 33 Homolog A (VPS33A))

Épitope: AA 1-300

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp VPS33A est conjugé à/à la HRP

Application: ELISA

Réactivité croisée: Humain

Purification: >95%, Protein G purified

Immunogène: Recombinant Human Vacuolar protein sorting-associated protein 33A protein (1-300AA)

Isotype: IgG

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C,-80 °C

Stockage commentaire: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Détails sur VPS33A

Antigène: VPS33A (Vacuolar Protein Sorting 33 Homolog A (VPS33A))

Autre désignation: VPS33A (VPS33A Produits)

Synonymes: anticorps r-Vps33a, anticorps VPS33A, anticorps vps33a, anticorps MGC145524, anticorps 3830421M04Rik, anticorps AI503300, anticorps AW048546, anticorps AW554476, anticorps bf, anticorps im:7136893, anticorps wu:fc08g01, anticorps wu:fc26c10, anticorps VPS33A CORVET/HOPS core subunit, anticorps VPS33A, CORVET/HOPS core subunit, anticorps vacuolar protein sorting 33 homolog A (S. cerevisiae), anticorps Vacuolar protein sorting 33A, anticorps VPS33A, CORVET/HOPS core subunit L homeolog, anticorps vacuolar protein sorting 33A, anticorps Vps33a, anticorps VPS33A, anticorps vps33a, anticorps CGB_E2330C, anticorps vps33a.L

Sujet:

Background: Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport and autophagic pathways. Believed to act as a core component of the putative HOPS and CORVET endosomal tethering complexes which are proposed to be involved in the Rab5-to-Rab7 endosome conversion probably implicating MON1A/B, and via binding SNAREs and SNARE complexes to mediate tethering and docking events during SNARE-mediated membrane fusion. The HOPS complex is proposed to be recruited to Rab7 on the late endosomal membrane and to regulate late endocytic, phagocytic and autophagic traffic towards lysosomes. The CORVET complex is proposed to function as a Rab5 effector to mediate early endosome fusion probably in specific endosome subpopulations (PubMed:23351085, PubMed:24554770, PubMed:25266290, PubMed:25783203). Required for fusion of endosomes and autophagosomes with lysosomes, the function is dependent on its association with VPS16 but not VIPAS39 (PubMed:25783203). The function in autophagosome-lysosome fusion implicates STX17 but not UVRAG (PubMed:24554770).

Aliases: VPS33AVacuolar protein sorting-associated protein 33A antibody, hVPS33A antibody

UniProt: Q96AX1