VPS4B anticorps

N° du produit ABIN7120711

Cet anticorps Lapin Polyclonal détecte spécifiquement VPS4B dans WB, ELISA, IP et IF. Il présente une réactivité envers Humain, Souris et Rat.

Aperçu rapide pour VPS4B anticorps (ABIN7120711)

Antigène: VPS4B (vps4b) (Vacuolar Protein Sorting 4 Homolog B (vps4b))

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp VPS4B est non-conjugé

Application: Western Blotting (WB), ELISA, Immunoprecipitation (IP), Immunofluorescence (IF)

Détail du produit anti-VPS4B anticorps

Fonction: VPS4B antibody

Purification: Immunogen affinity purified

Pureté: ≥95 % as determined by SDS-PAGE

Immunogène: vacuolar protein sorting 4 homolog B

Isotype: IgG

Information d'application

Indications d'application: WB: 1:500-1:5000,IP: 1:500-1:5000,IF: 1:10-1:100

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freeze / thaw cycles.

Stock: -20 °C

Stockage commentaire: -20°C for 12 months

Date de péremption: 12 months

Détails sur VPS4B

Antigène: VPS4B (vps4b) (Vacuolar Protein Sorting 4 Homolog B (vps4b))

Autre désignation: VPS4B

Sujet:

Synonyms: Vacuolar protein sorting-associated protein 4B|Cell migration-inducing gene 1 protein|Suppressor of K(+) transport growth defect 1 (Protein SKD1)|VPS4B|SKD1|VPS42

Background: Involved in late steps of the endosomal multivesicular bodies(MVB) pathway. Recognizes membrane-associated ESCRT-III assemblies and catalyzes their disassembly, possibly in combination with membrane fission. Redistributes the ESCRT-III components to the cytoplasm for further rounds of MVB sorting. MVBs contain intraluminal vesicles(ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. In conjunction with the ESCRT machinery also appears to function in topologically equivalent membrane fission events, such as the terminal stages of cytokinesis and enveloped virus budding(HIV-1 and other lentiviruses). VPS4A/B are required for the exosomal release of SDCBP, CD63 and syndecan(PubMed:22660413).

Poids moléculaire: 50 kDa

ID gène: 9525

UniProt: O75351

Pathways: Dynamique des Microtubules, CXCR4-mediated Signaling Events