GPR177/WLS anticorps (AA 43-234)

N° du produit ABIN7120857

Cet anticorps anti-GPR177/WLS est un anticorps Lapin Polyclonal détectant GPR177/WLS dans ELISA, WB, IHC et IP. Adapté pour Humain, Souris et Rat.

Aperçu rapide pour GPR177/WLS anticorps (AA 43-234) (ABIN7120857)

Antigène: GPR177/WLS (WLS) (Wntless Homolog (WLS))

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp GPR177/WLS est non-conjugé

Application: ELISA, Western Blotting (WB), Immunohistochemistry (IHC), Immunoprecipitation (IP)

Détail du produit anti-GPR177/WLS anticorps

Épitope: AA 43-234

Fonction: WLS antibody

Purification: Immunogen affinity purified

Pureté: ≥95 % as determined by SDS-PAGE

Immunogène:

Immunogen sequence: 43-234aa

Immunogen: G protein-coupled receptor 177

Isotype: IgG

Information d'application

Indications d'application: WB: 1:500-1:1000, IP: 1:500-1:1000, IHC: 1:20-1:200

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freeze / thaw cycles.

Stock: -20 °C

Stockage commentaire: -20°C for 12 months

Date de péremption: 12 months

Détails sur GPR177/WLS

Antigène: GPR177/WLS (WLS) (Wntless Homolog (WLS))

Autre désignation: WLS

Sujet:

Synonyms: Protein wntless homolog|Integral membrane protein GPR177|Protein evenness interrupted homolog (EVI)|Putative NF-kappa-B-activating protein 373|WLS|C1orf139|GPR177

Background: GPR177, also known as Wntless (WLS) or Evi, is an evolutionarily conserved transmembrane protein necessary for Wnt protein secretion. GPR177 localizes to compartments of the secretory pathway, including the ER, Golgi apparatus, endosomes, and plasma membrane. GPR177 is overexpressed in several cancer types including glioma and gastric cancer. Several isoforms of GPR177 exist due to the alternative splicing, with predicted MW around 62 and 51 kDa, respectively. The sequence can be processed by removing the signal peptide, which generates a mature form of 45-46 kDa. In addition, slow migragrating band above 62 kDa can also be detected because GPR177 is modified by N-linked glycosylation (PMID: 20549736).

Poids moléculaire: 46-62 kDa

ID gène: 79971

UniProt: Q5T9L3

Pathways: Signalisation WNT