WWP1 anticorps

N° du produit ABIN7120866

Cet anticorps anti-WWP1 est un anticorps Lapin Polyclonal détectant WWP1 dans WB, ELISA, IP, IHC et IF. Adapté pour Humain, Souris et Rat.

Aperçu rapide pour WWP1 anticorps (ABIN7120866)

Antigène: WWP1 (WW Domain Containing E3 Ubiquitin Protein Ligase 1 (WWP1))

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp WWP1 est non-conjugé

Application: Western Blotting (WB), ELISA, Immunoprecipitation (IP), Immunohistochemistry (IHC), Immunofluorescence (IF)

Détail du produit anti-WWP1 anticorps

Fonction: WWP1 antibody

Purification: Immunogen affinity purified

Pureté: ≥95 % as determined by SDS-PAGE

Immunogène: WW domain containing E3 ubiquitin protein ligase 1

Isotype: IgG

Information d'application

Indications d'application: WB: 1:200-1:2000, IP: 1:200-1:1000, IF: 1:20-1:200

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freeze / thaw cycles.

Stock: -20 °C

Stockage commentaire: -20°C for 12 months

Date de péremption: 12 months

Détails sur WWP1

Antigène: WWP1 (WW Domain Containing E3 Ubiquitin Protein Ligase 1 (WWP1))

Autre désignation: WWP1

Sujet:

Synonyms: NEDD4-like E3 ubiquitin-protein ligase WWP1|Atrophin-1-interacting protein 5 (AIP5)|HECT-type E3 ubiquitin transferase WWP1|TGIF-interacting ubiquitin ligase 1 (Tiul1)|WW domain-containing protein 1|WWP1

Background: E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Ubiquitinates ERBB4 isoforms JM-A CYT-1 and JM-B CYT-1, KLF2, KLF5 and TP63 and promotes their proteasomal degradation. Ubiquitinates RNF11 without targeting it for degradation. Ubiquitinates and promotes degradation of TGFBR1, the ubiquitination is enhanced by SMAD7. Ubiquitinates SMAD6 and SMAD7. Ubiquitinates and promotes degradation of SMAD2 in response to TGF-beta signaling, which requires interaction with TGIF.

Poids moléculaire: 90-110 kDa

ID gène: 11059

UniProt: Q9H0M0