YTHDC1 anticorps

N° du produit ABIN7120901

L’anticorps Lapin Polyclonal anti-YTHDC1 a été validé pour WB et ELISA. Il convient pour détecter YTHDC1 dans des échantillons de Humain, Souris et Rat.

Aperçu rapide pour YTHDC1 anticorps (ABIN7120901)

Antigène: YTHDC1 (YTH Domain Containing 1 (YTHDC1))

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp YTHDC1 est non-conjugé

Application: Western Blotting (WB), ELISA

Détail du produit anti-YTHDC1 anticorps

Fonction: YTHDC1 antibody

Purification: Immunogen affinity purified

Pureté: ≥95 % as determined by SDS-PAGE

Immunogène: YTH domain containing 1

Isotype: IgG

Information d'application

Indications d'application: WB: 1:200-1:1000

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freeze / thaw cycles.

Stock: -20 °C

Stockage commentaire: -20°C for 12 months

Date de péremption: 12 months

Détails sur YTHDC1

Antigène: YTHDC1 (YTH Domain Containing 1 (YTHDC1))

Autre désignation: YTHDC1

Sujet:

Synonyms: YTH domain-containing protein 1|Splicing factor YT521 (YT521-B)|YTHDC1|KIAA1966|YT521

Background: Regulator of alternative splicing that specifically recognizes and binds N6-methyladenosine(m6A)-containing RNAs(PubMed:26318451, PubMed:26876937, PubMed:25242552). M6A is a modification present at internal sites of mRNAs and some non-coding RNAs and plays a role in the efficiency of mRNA splicing, processing and stability(PubMed:26318451, PubMed:25242552). Acts as a key regulator of exon-inclusion or exon-skipping during alternative splicing via interaction with mRNA splicing factors SRSF3 and SRSF10(PubMed:26876937). Specifically binds m6A-containing mRNAs and promotes recruitment of SRSF3 to its mRNA-binding elements adjacent to m6A sites, leading to exon-inclusion during alternative splicing(PubMed:26876937). In contrast, interaction with SRSF3 prevents interaction with SRSF10, a splicing factor that promotes exon skipping: this prevents SRSF10 from binding to its mRNA-binding sites close to m6A-containing regions, leading to inhibit exon skipping during alternative splicing(PubMed:26876937). May also regulate alternative splice site selection(PubMed:20167602).

Poids moléculaire: 110 kDa

ID gène: 91746

UniProt: Q96MU7