ECD/SGT1 anticorps

N° du produit ABIN7126219

Détail du produit anti-ECD/SGT1 anticorps

Antigène: ECD/SGT1 (ECD) (Ecdysoneless Homolog (ECD))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp ECD/SGT1 est non-conjugé

Application: Immunoprecipitation (IP), Immunofluorescence (IF), Flow Cytometry (FACS)

Specificité: Inhibits MDM2-mediated degradation of p53/TP53 possibly by cooperating in part with TXNIP. May be involved transcriptional regulation. In vitro has intrinsic transactivation activity enhanced by EP300. May be a transcriptional activator required for the expression of glycolytic genes. Involved in regulation of cell cycle progression. Proposed to disrupt Rb-E2F binding leading to transcriptional activation of E2F proteins. The cell cycle -regulating function may depend on its RUVBL1-mediated association with the R2TP complex. May play a role in regulation of pre-mRNA splicing.

Réactivité croisée (Details): Human. Predicted to react with Rabbit, Goat, Horse, Guinea pig, Dog, Pig, Rhesus monkey, Orangutan and Elephant (based on sequence homology).

Purification: 1.0mg/ml of Ab purified from Bioreactor by Protein A/G.

Immunogène: Recombinant full-length human ECD protein

Isotype: IgG2b

Information d'application

Indications d'application:

Known_Application: Immunoprecipitation (1-2 μg per 100-500 μg of total protein), ,Flow Cytometry (1-2 μg/million cells), Immunofluorescence (1-2 μg/mL), ,Optimal dilution for a specific application should be determined.

Positive_Control: HeLa or 293T cells. Human testis, spleen or colon.

Restrictions: For Research Use only

Stockage

Concentration: 1.0 mg/mL

Buffer: Prepared in 10 mM PBS, WITHOUT BSA and Azide.

Agent conservateur: Azide free

Stock: -20 °C,-80 °C

Stockage commentaire: Antibody without azide - store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous.

Date de péremption: 24 months

Détails sur ECD/SGT1

Antigène: ECD/SGT1 (ECD) (Ecdysoneless Homolog (ECD))

Autre désignation: ECD (ECD Produits)

Synonymes: anticorps GCR2, anticorps HSGT1, anticorps 5730461K03Rik, anticorps Hsgt1, anticorps ecdysoneless cell cycle regulator, anticorps ecdysoneless homolog (Drosophila), anticorps ECD, anticorps Ecd

Sujet: Ecdysoneless homolog, hSGT1, Human suppressor of GCR two, Protein ecdysoneless homolog, SGT1 protein,ECD / SGT1
Cellular localisation: Nucleus. Cytosol.

Poids moléculaire: 72.76kDa

ID gène: 11319, 631822

UniProt: O95905

Pathways: Regulation of Carbohydrate Metabolic Process